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FLASH GENE
Symbol PAFAH2 contributors: - updated : 06-10-2005
HGNC name platelet-activating factor acetylhydrolase 2, 40kDa
HGNC id 8579
Location 1p34.2      Physical location : 26.286.259 - 26.324.648
Synonym symbol(s) HSD-PLA2
EC.number 3.1.1.47
DNA
TYPE functioning gene
STRUCTURE 37.00 kb     11 Exon(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Map pter - D1S2843 - D1S2732 - D1S478 - D1S2864 - C1QB C1QB - D1S482 - PAFAH2 - D1S2674 - D1S2749 - D1S2639 - D1S247 - D1S2676 - D1S2613 - D1S2830 - D1S2729 - D1S432 - D1S2645 - D1S193 - D1S443 - D1S2724 - D1S2661 - D1S417 - cen
Authors GeneMap (98)
Physical map
LOC388606 1 similar to Succinate dehydrogenase [ubiquinone] cytochrome B small subunit, mitochondrial precursor (CybS) (Succinate-ubiquinone reductase membrane anchor subunit) (QPS2) (CII-4) (Succinate dehydrogenase complex subunit D) (Succinat RHD 1p36.1 Rhesus blood group, D antigen LOC388607 1 similar to RhCE protein LOC388608 1 similar to mutant membrane protein RhCe FLJ10747 1p36.11 hypothetical protein FLJ10747 ARH MAN1C1 1p35 mannosidase, alpha, class 1C, member 1 SEPN1 1p36.13 selenoprotein N, 1 LOC56181 1p35.3 hypothetical protein RP1-317E23 MGC2603 1p35.3 hypothetical protein MGC2603 MPRA 1p36.11 hypothetical protein MGC2603 FLJ32206 1p35.3 hypothetical protein FLJ32206 STMN1 1p36.11 stathmin 1/oncoprotein 18 LOC388609 1 LOC388609 PAFAH2 1p34.2 platelet-activating factor acetylhydrolase 2, 40kDa EXTL1 1p36.1 exostoses (multiple)-like 1 SLC30A2 1p35.3 solute carrier family 30 (zinc transporter), member 2 RNF28 1p34-p33 ring finger protein 28 LOC149420 1p35.3 casein kinase FLJ14050 1p35.3 hypothetical protein FLJ14050 ZT86 1p35.3 zinc finger protein CNK1 1p35.3 zinc finger protein CATSPER4 1p35.3 cation channel, sperm associated 4 LOC391021 1 similar to secreted acid phosphatase 2 (SAP2) DKFZP434L0117 1p35.3 hypothetical protein DKFZp434L0117 MRPS6P1 1p35 mitochondrial ribosomal protein S6 pseudogene 1 SH3BGRL3 1p35-p34.3 SH3 domain binding glutamic acid-rich protein like 3 SOC 1p35.3 SH3 domain binding glutamic acid-rich protein like 3 CDW52 1p36 CDW52 antigen (CAMPATH-1 antigen) AIM1L 1p35.3 absent in melanoma 1-like MGC33414 1p35.3 hypothetical protein MGC33414 LIN28 1p35.3 lin-28 homolog (C. elegans) DHDDS 1p35.3 dehydrodolichyl diphosphate synthase HMGN2 1p36.1 high-mobility group nucleosomal binding domain 2 RPS6KA1 1p36-p35 ribosomal protein S6 kinase, 90kDa, polypeptide 1
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Lymphoid/Immunespleen   predominantly
Reproductivefemale systemovary  moderately
 female systemplacenta  moderately
 female systemuteruscervix highly
Respiratorylung   highly
 respiratory tractlarynx  moderately
Skin/Tegumentskin   highly
Urinarykidney   highly
Visualeye   moderately
cell lineage
cell lines
fluid/secretion serum
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a GLY - Ser - X - GLY motif, characteristic of lipases and serine esterases
  • mono polymer monomer
    HOMOLOGY
    interspecies ortholog to rattus Pafah2
    ortholog to murine Pafah2
    homolog to C. elegans paf-1
    Homologene
    FAMILY
  • serine esterase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • having a high activity for oxidized phospholipids
  • has a marked selectivity for phospholipids with short acyl chains at the sn-2 position
  • may share a common physiologic function with the plasma-type enzyme
  • catalyzing the removal of the acetyl group at the SN-2 position of platelet-activating factor (identified as 1-O-alkyl-2-acetyl-sn-glyceryl-3-phosphorylcholine)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
  • lipid degradation
  • a component
    INTERACTION
    DNA
    RNA
    small molecule other,
  • phospholipid
  • protein
    cell & other
    REGULATION
    inhibited by phenylmethanesulfonyl fluoride, 3, 4, dichloroisocoumarin, diisopropyl fluorophosphate (DFP)
    diethyl p-nitrophenyl phosphate (DENP)
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS