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FLASH GENE
Symbol PAFAH2 contributors: - updated : 06-10-2005
HGNC name platelet-activating factor acetylhydrolase 2, 40kDa
HGNC id 8579
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Lymphoid/Immunespleen   predominantly
Reproductivefemale systemovary  moderately
 female systemplacenta  moderately
 female systemuteruscervix highly
Respiratorylung   highly
 respiratory tractlarynx  moderately
Skin/Tegumentskin   highly
Urinarykidney   highly
Visualeye   moderately
cell lineage
cell lines
fluid/secretion serum
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a GLY - Ser - X - GLY motif, characteristic of lipases and serine esterases
  • mono polymer monomer
    HOMOLOGY
    interspecies ortholog to rattus Pafah2
    ortholog to murine Pafah2
    homolog to C. elegans paf-1
    Homologene
    FAMILY
  • serine esterase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • having a high activity for oxidized phospholipids
  • has a marked selectivity for phospholipids with short acyl chains at the sn-2 position
  • may share a common physiologic function with the plasma-type enzyme
  • catalyzing the removal of the acetyl group at the SN-2 position of platelet-activating factor (identified as 1-O-alkyl-2-acetyl-sn-glyceryl-3-phosphorylcholine)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
  • lipid degradation
  • a component
    INTERACTION
    DNA
    RNA
    small molecule other,
  • phospholipid
  • protein
    cell & other
    REGULATION
    inhibited by phenylmethanesulfonyl fluoride, 3, 4, dichloroisocoumarin, diisopropyl fluorophosphate (DFP)
    diethyl p-nitrophenyl phosphate (DENP)
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS