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FLASH GENE
Symbol PAFAH2 contributors: - updated : 06-10-2005
HGNC name platelet-activating factor acetylhydrolase 2, 40kDa
HGNC id 8579
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a GLY - Ser - X - GLY motif, characteristic of lipases and serine esterases
    • mono polymer monomer
    HOMOLOGY
    interspecies ortholog to rattus Pafah2
    ortholog to murine Pafah2
    homolog to C. elegans paf-1
    Homologene
    FAMILY
  • serine esterase family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • having a high activity for oxidized phospholipids
  • has a marked selectivity for phospholipids with short acyl chains at the sn-2 position
  • may share a common physiologic function with the plasma-type enzyme
  • catalyzing the removal of the acetyl group at the SN-2 position of platelet-activating factor (identified as 1-O-alkyl-2-acetyl-sn-glyceryl-3-phosphorylcholine)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
  • lipid degradation
    • a component
    INTERACTION
    DNA
    RNA
    small molecule other,
  • phospholipid
    • protein
    cell & other
    REGULATION
    inhibited by phenylmethanesulfonyl fluoride, 3, 4, dichloroisocoumarin, diisopropyl fluorophosphate (DFP)
    diethyl p-nitrophenyl phosphate (DENP)
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS