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FLASH GENE

Symbol

OSBPL9

contributors: mct/npt - updated : 19-06-2010

HGNC name	oxysterol binding protein-like 9
HGNC id	16386

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	1p32.3      Physical location : 52.082.546 - 52.254.889
Synonym name	OSBP-related protein 9
Synonym symbol(s)	ORP9, FLJ14801, FLJ14629, FLJ34384, FLJ32055, MGC15035, FLJ12492, OSBP4, ORP-9

DNA

TYPE	functioning gene
STRUCTURE	171.38 kb     24 Exon(s)

Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_148904 20 - 2847 NP_683702 - 558 - Lessmann (2007), Wyles (2004) also called OSBPL9S or variant 1/isoform a ORP9S, an N-terminal truncated version of full-length ORP9L novel PKC-beta substrate truncated version missing the PH domain NM_024586 24 - 2919 NP_078862 - 736 - Lehto (2001) also called variant 6/isoform e NM_148905 19 - 2751 NP_683703 - 558 - Lehto (2001) also called variant 2/isoform a NM_148906 23 - 2840 NP_683704 - 571 - Lehto (2001) also called variant 3/isoform b NM_148907 20 - 2694 NP_683705 - 626 - Lehto (2001) also called variant 4/isoform c NM_148908 23 - 2880 NP_683706 - 723 - Lehto (2001) also called variant 5/isoform d NM_148909 24 - 2949 NP_683707 - 746 - Lehto (2001), Lessmann (2007) also called OSBPL9L or variant 7/isoform f

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	N terminal pleckstrin homology PH domain
	FFAT motif interacting with the N-terminal conserved domain of VAPA (Wyles 2004)
	a highly conserved OSBP-type sterol binding domain in the C terminus

HOMOLOGY

Homologene

FAMILY

oxysterol binding protein (OSBP) family

CATEGORY

transport carrier

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,endoplasmic reticulum
text	localize to organellar membranes, reflecting a functional role in sterol signaling and/or transport (Ngo 2009)
	localized to the ER-Golgi, but its role in secretion and lipid transport is unknown (Ngo 2009)

basic FUNCTION	implicated in lipid transport and metabolism, vesicle trafficking and cell signaling (Lessmann 2007)
	maintains the integrity of the early secretory pathway by mediating transport of sterols between the ER and trans-Golgi/TGN (Ngo 2009)

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

cellular trafficking transport

PATHWAY

metabolism

lipid/lipoprotein

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	PDK2 substrate and negative regulator of Akt phosphorylation at the PDK2 site) (Lessmann 2007)
	interacting with VAPA (VAMP-associated protein-A regulates partitioning of OSBPL9 between the endoplasmic reticulum and Golgi apparatus, and VAPA binding and PH domains target OSBPL9 to the ER and a Golgi-COPII compartment, respectively (Wyles 2004)

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS