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FLASH GENE
Symbol OSBPL9 contributors: mct/npt - updated : 19-06-2010
HGNC name oxysterol binding protein-like 9
HGNC id 16386
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N terminal pleckstrin homology PH domain
  • FFAT motif interacting with the N-terminal conserved domain of VAPA (Wyles 2004)
  • a highly conserved OSBP-type sterol binding domain in the C terminus
    • HOMOLOGY
    Homologene
    FAMILY
  • oxysterol binding protein (OSBP) family
    • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    text
  • localize to organellar membranes, reflecting a functional role in sterol signaling and/or transport (Ngo 2009)
  • localized to the ER-Golgi, but its role in secretion and lipid transport is unknown (Ngo 2009)
    • basic FUNCTION
  • implicated in lipid transport and metabolism, vesicle trafficking and cell signaling (Lessmann 2007)
  • maintains the integrity of the early secretory pathway by mediating transport of sterols between the ER and trans-Golgi/TGN (Ngo 2009)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • PDK2 substrate and negative regulator of Akt phosphorylation at the PDK2 site) (Lessmann 2007)
  • interacting with VAPA (VAMP-associated protein-A regulates partitioning of OSBPL9 between the endoplasmic reticulum and Golgi apparatus, and VAPA binding and PH domains target OSBPL9 to the ER and a Golgi-COPII compartment, respectively (Wyles 2004)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS