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FLASH GENE
Symbol OSBPL9 contributors: mct/npt - updated : 19-06-2010
HGNC name oxysterol binding protein-like 9
HGNC id 16386
DNA
TYPE functioning gene
STRUCTURE 171.38 kb     24 Exon(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
ELAVL4 1p34 ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D) LOC343184 1p33 similar to ribosomal protein S2 LOC391038 1 similar to Protein C14orf111 (CGI-35) DMRTA2 1p33 DMRT-like family A2 FAF1 1p33 Fas (TNFRSF6) associated factor 1 MRPS6P2 1p33 mitochondrial ribosomal protein S6 pseudogene 2 LOC51336 1p32.3 mesenchymal stem cell protein DSCD28 CDKN2C 1p32 cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) LOC284546 1p32.3 similar to RIKEN cDNA 4930522H14 LOC391039 1 similar to Cofilin, non-muscle isoform (18 kDa phosphoprotein) (P18) RNF11 1p32-p31 ring finger protein 11 LOC388631 1 similar to ribosomal protein S2; 40S ribosomal protein S2 C1orf34 1p33 chromosome 1 open reading frame 34 EPS15 1p32.2-p31 epidermal growth factor receptor pathway substrate 15 OSBPL9 1p34.2-p32.2 oxysterol binding protein-like 9 NRD1 1p32.2 nardilysin (N-arginine dibasic convertase) RAB3B 1p32-p31 RAB3B, member RAS oncogene family TLP19 1p32.3 endoplasmic reticulum thioredoxin superfamily member, 18 kDa LOC112970 1p32.3 hypothetical protein BC012173 LOC391040 1 similar to RIKEN cDNA 5730434I03 gene MADHIP 1p32.3 MAD, mothers against decapentaplegic homolog (Drosophila) interacting protein, receptor activation anchor KIAA1836 1p32.3 KIAA1836 protein ORC1L 1p32 origin recognition complex, subunit 1-like (yeast) FLJ14936 1p33-p32.1 hypothetical protein FLJ14936 KIAA0191 1p31-32 hypothetical protein FLJ14936 GPX6 6p21.33 glutathione peroxidase 6 (olfactory) MGC52498 1p32.3 hypothetical protein MGC52498 FLJ12439 1p32.3 hypothetical protein FLJ12439 FLJ13456 1p32.3 hypothetical protein FLJ13456 FLJ10948 1p32.3 hypothetical protein FLJ10948 SCP2 1p32 sterol carrier protein 2 PODN 1p32.3 podocan SLC1A7 1p33 solute carrier family 1 (glutamate transporter), member 7 CPT2 1p32 carnitine palmitoyltransferase II FLJ20580 1p32.3 hypothetical protein FLJ20580 MAGOH 1p34-p33 mago-nashi homolog, proliferation-associated (Drosophila) LRP8 1p34 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor FLJ40434 1p32.3 hypothetical protein FLJ40434 DMRTB1 1p33 DMRT-like family B with proline-rich C-terminal, 1 FLJ36155 1p32.3 likely ortholog of mouse Gli-similar 1 Kruppel-like zinc finger (Glis1) FLJ10407 1p32.3 hypothetical protein FLJ10407
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
20 - 2847 - 558 - Lessmann (2007), Wyles (2004)
  • also called OSBPL9S or variant 1/isoform a
  • ORP9S, an N-terminal truncated version of full-length ORP9L
  • novel PKC-beta substrate
  • truncated version missing the PH domain
  • 24 - 2919 - 736 - Lehto (2001)
    also called variant 6/isoform e
    19 - 2751 - 558 - Lehto (2001)
    also called variant 2/isoform a
    23 - 2840 - 571 - Lehto (2001)
    also called variant 3/isoform b
    20 - 2694 - 626 - Lehto (2001)
    also called variant 4/isoform c
    23 - 2880 - 723 - Lehto (2001)
    also called variant 5/isoform d
    24 - 2949 - 746 - Lehto (2001), Lessmann (2007)
    also called OSBPL9L or variant 7/isoform f
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N terminal pleckstrin homology PH domain
  • FFAT motif interacting with the N-terminal conserved domain of VAPA (Wyles 2004)
  • a highly conserved OSBP-type sterol binding domain in the C terminus
  • HOMOLOGY
    Homologene
    FAMILY
  • oxysterol binding protein (OSBP) family
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    text
  • localize to organellar membranes, reflecting a functional role in sterol signaling and/or transport (Ngo 2009)
  • localized to the ER-Golgi, but its role in secretion and lipid transport is unknown (Ngo 2009)
  • basic FUNCTION
  • implicated in lipid transport and metabolism, vesicle trafficking and cell signaling (Lessmann 2007)
  • maintains the integrity of the early secretory pathway by mediating transport of sterols between the ER and trans-Golgi/TGN (Ngo 2009)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • PDK2 substrate and negative regulator of Akt phosphorylation at the PDK2 site) (Lessmann 2007)
  • interacting with VAPA (VAMP-associated protein-A regulates partitioning of OSBPL9 between the endoplasmic reticulum and Golgi apparatus, and VAPA binding and PH domains target OSBPL9 to the ER and a Golgi-COPII compartment, respectively (Wyles 2004)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS