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FLASH GENE
Symbol OPN1MW contributors: mct/ - updated : 01-07-2008
HGNC name opsin 1 (cone pigments), medium-wave-sensitive
HGNC id 4206
Corresponding disease
CBBM1 colorblindness blue cone monochromatism 1
CBD colorblindness, deutan, daltonism
CORDX5 cone-rod dystrophy 5
Location Xq28      Physical location : 153.448.084 - 153.499.469
Synonym name
  • green cone pigment
  • color blindness, deutan
  • green cone photoreceptor pigment
  • Synonym symbol(s) GCP, OPSG, CBBM, CBD, OPN1MW1, GOP, OPN1MW2, MGC198469, MGC198468, MGC177321, MGC176615
    DNA
    TYPE functioning gene
    STRUCTURE 13.37 kb     6 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked Y status confirmed
    Map cen - OPN1LW - DXS498 - DXS499 - OPN1MW (GCP:0 to 6) - qter
    Authors Neitz (95)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 1998 40.6 364 - 2002 12051694
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunespleen    
    Visualeyeretina   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsensoryvisual  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Visualcone photoreceptor
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text eye
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • seven transmembrane segments (7TM) receptor
  • HOMOLOGY
    Homologene
    FAMILY
  • G-protein coupled receptor 1 family
  • Opsin subfamily
  • CATEGORY receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • medium wave photon absorption with a maximum at 530 nm (in the green)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS nervous system
    PATHWAY
    metabolism
    signaling sensory transduction/vision
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    activated by OPN1MW (Liu 2007)
    ASSOCIATED DISORDERS
    corresponding disease(s) CBD , CBBM1 , CORDX5
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS