Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Orphanet	Ensembl
	HGNC	UniGene	Nucleotide	OMIM		UCSC

Home Page

FLASH GENE

Symbol

OPN1LW

contributors: mct - updated : 23-12-2017

HGNC name	opsin 1 (cone pigments), long-wave-sensitive
HGNC id	9936

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Corresponding disease	CBP color blindness, protan series, partial CORDX5 cone-rod dystrophy 5
Location	Xq28      Physical location : 153.409.724 - 153.424.505
Synonym name	opsin 1 (cone pigments), long-wave-sensitive (color blindness, protan)
	color blindness, protan
	red cone photoreceptor pigment
	red-sensitive opsin
Synonym symbol(s)	RCP, OPSR, CBBM, ROP, CBP,

DNA

TYPE	functioning gene
STRUCTURE	14.78 kb     6 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

Y

status

confirmed

Map	cen - (OPN1LW ) - DXS498 - DXS499 - OPN1MW (1 to 7) - qter
Authors	Neitz (95)

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_020061 6 - 1234 NP_064445 40.4 364 - Liu (2007)

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Visual eye retina         eye uvea choroid

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial sensory visual

cells

System Cell Pubmed Species Stage Rna symbol Visual cone photoreceptor

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

fetal

Text

eye

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

seven transmembrane (7TM) receptor

HOMOLOGY

Homologene

FAMILY	G-protein coupled receptor 1 family
	Opsin subfamily

CATEGORY

receptor

SUBCELLULAR LOCALIZATION

plasma membrane

basic FUNCTION

long wave photon absorption with a maximum at 560 nm (in the yellow-green)

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

sensory transduction/vision

a component

INTERACTION

DNA

RNA

small molecule

protein

opsin expression in terminally differentiated mammalian cones remains subject to control by TH (Thyroid hormone)

cell & other

REGULATION

activated by

TH (Liu 2007)

ASSOCIATED DISORDERS

corresponding disease(s)

CBP , CORDX5

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS