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FLASH GENE

Symbol

OLFM1

contributors: mct - updated : 28-03-2018

HGNC name	olfactomedin 1
HGNC id	17187

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	9q34.3      Physical location : 137.967.088 - 138.013.031
Synonym name	noelin
	olfactomedin related ER localized protein
	pancortin 1
Synonym symbol(s)	AMY, NOE1, NOELIN, NOELIN1, NOELIN1_V1, NOELIN1_V2, NOELIN1_V4, OlfA, hOlfA

DNA

TYPE	functioning gene
STRUCTURE	45.94 kb     2 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_014279 6 - 2879 NP_055094 53 467 - 2016 27555280 OLFM-I1 NM_006334 4 splicing 1212 NP_006325 - 135 - 2016 27555280 OLFM-I2 OLFM-I3 - splicing 980 - 169 - 2016 27555280 OLFM-I4 - splicing 1300 55 485 - 2016 27555280 NM_001282612 5 - 2502 NP_001269541 - 458 - 2016 27555280 NM_001282611 6 - 2791 NP_001269540 - 485 - 2016 27555280

EXPRESSION

Type

expressed in

(based on citations)

organ(s)

System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain       highly Homo sapiens   brain forebrain cerebral cortex     Homo sapiens   brain limbic system hippocampus     Homo sapiens   ganglia sensory ganglia dorsal root     Mus musculus   nerve cranial nerve optic nerve     Mus musculus Olfactory (smell) olfactory bulb         Homo sapiens Visual eye retina       Mus musculus   eye anterior segment cornea     Mus musculus   eye sclera       Mus musculus

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Nervous central       Homo sapiens Nervous peripherous       Homo sapiens

cells

System Cell Pubmed Species Stage Rna symbol Visual ganglion cell Mus musculus

cell lineage
cell lines	neuroblastoma cell lines
fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	N-terminal signal peptide
	followed by a coiled-coil domain
	an olfactomedin domain located in the C-terminal

conjugated

GlycoP

HOMOLOGY

interspecies	homolog to murine Olfm1
	homolog to C.elegans R166.5

Homologene

FAMILY

olfactomedin domain-containing proteins family

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION	extracellular
	intracellular
	intracellular,cytoplasm,organelle,endoplasmic reticulum
text	OLFM1 staining was equally strong in the endoplasmic reticulum and the growth cones

basic FUNCTION	playing a role in regulating the production of neural crest by the neural tube
	participates in neural progenitor maintenance, cell death in brain, and optic nerve arborization
	localization of OLFM1 in the growth cones of neuronal cells suggests that it may play a role in axon growth and/or guidance
	OLFM1 is a component of neuronal growth cones and is a novel soluble ligand of RTN4R, which regulates axonal outgrowth and axon bundle formation during brain development
	is a highly expressed neuronal glycoprotein important for nervous system development
	potential role for OLFM1 in clustering receptors to regulate signaling and sheds light on the conformation of several other olfactomedin domain family members

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

development

text	neurogenesis

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	OLFM1 is a novel RTN4R ligand that modulates the functions of the RTN4R complex in axonal growth
	binding of RTN4R and LINGO1 was similarly inhibited by OLFM1 coexpression
	is an endogenous antagonist of myelin-associated axon growth inhibitors

cell & other

REGULATION

Other

stabilized by calcium

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional       loss of function leads to defective olfaction and impaired female fertility ( tumoral     --low   in primary Colorectal cancer samples compared to adjacent non-cancerous tissues

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	may be a valuable biomarker for CRC patients (pMID: 27555280)
Therapy target
	System Type Disorder Pubmed neurology acquired   application of OLFM1 or stimulation of its expression may be used to facilitate neuronal growth after axonal damage or injury cancer digestive colon may be a valuable therapeutic target for Colorectal cancer patients

ANIMAL & CELL MODELS

	Olfm1(-/-) female mice were previously reported to have reduced fertility
	olfactory system was both structurally and functionally disturbed by the mutation in the Olfm1 gene which may contribute to the neonatal death and loss of body weight of Olfm1 mutant