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FLASH GENE
Symbol OLFM1 contributors: mct - updated : 28-03-2018
HGNC name olfactomedin 1
HGNC id 17187
Location 9q34.3      Physical location : 137.967.088 - 138.013.031
Synonym name
  • noelin
  • olfactomedin related ER localized protein
  • pancortin 1
  • Synonym symbol(s) AMY, NOE1, NOELIN, NOELIN1, NOELIN1_V1, NOELIN1_V2, NOELIN1_V4, OlfA, hOlfA
    DNA
    TYPE functioning gene
    STRUCTURE 45.94 kb     2 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC158226 9q34.3 hypothetical LOC158226 RXRA 9q34.3 retinoid X receptor, alpha LOC157943 9q34.3 hypothetical LOC157943 COL5A1 9q34.3 collagen, type V, alpha 1 LOC389804 9 LOC389804 LOC392397 9 similar to hypothetical protein FCN2 9q34 ficolin (collagen/fibrinogen domain containing lectin) 2 (hucolin) FCN1 9q34 ficolin (collagen/fibrinogen domain containing) 1 OLFM1 9q34.3 olfactomedin 1 LOC392398 9 similar to ligand-independent activating molecule for estrogen receptor C9orf62 9q34.3 chromosome 9 open reading frame 62 KIAA0649 9q34.3 chromosome 9 open reading frame 62 MGC29761 9q34.3 hypothetical protein MGC29761 MRPS2 9q34 mitochondrial ribosomal protein S2 LCN1 9q34 lipocalin 1 (protein migrating faster than albumin, tear prealbumin) OBP2A 9q34 lipocalin 1 (protein migrating faster than albumin, tear prealbumin) PAEP 9q34.2-q34.3 progestagen-associated endometrial protein (placental protein 14, pregnancy-associated endometrial alpha-2-globulin, alpha uterine protein) LOC138159 9q34.3 beta-lactoglobulin pseudogene GLTDC1 9q34.3 galactosyltransferase family 6 domain containing 1 LOC392399 9 similar to Putative MUP-like lipocalin precursor LOC286220 9q34.3 hypothetical protein LOC286220 KCNT1 9q34.3 potassium channel, subfamily T, member 1 CAMSAP1 9q34.3 calmodulin regulated spectrin-associated protein 1 LOC389805 9 similar to 9530003A05 protein GBDR1 9q34.1-q34.3 similar to 9530003A05 protein BTBD14A 9q34.3 BTB (POZ) domain containing 14A
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 2879 53 467 - 2016 27555280
    OLFM-I1
    4 splicing 1212 - 135 - 2016 27555280
    OLFM-I2
    - splicing 980 - 169 - 2016 27555280
    - splicing 1300 55 485 - 2016 27555280
    5 - 2502 - 458 - 2016 27555280
    6 - 2791 - 485 - 2016 27555280
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain   highly Homo sapiens
     brainforebraincerebral cortex   Homo sapiens
     brainlimbic systemhippocampus   Homo sapiens
     gangliasensory gangliadorsal root   Mus musculus
     nervecranial nerveoptic nerve   Mus musculus
    Olfactory (smell)olfactory bulb     Homo sapiens
    Visualeyeretina    Mus musculus
     eyeanterior segmentcornea   Mus musculus
     eyesclera    Mus musculus
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Nervouscentral    Homo sapiens
    Nervousperipherous    Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Visualganglion cell Mus musculus
    cell lineage
    cell lines neuroblastoma cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminal signal peptide
  • followed by a coiled-coil domain
  • an olfactomedin domain located in the C-terminal
  • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to murine Olfm1
    homolog to C.elegans R166.5
    Homologene
    FAMILY olfactomedin domain-containing proteins family
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    text
  • OLFM1 staining was equally strong in the endoplasmic reticulum and the growth cones
  • basic FUNCTION
  • playing a role in regulating the production of neural crest by the neural tube
  • participates in neural progenitor maintenance, cell death in brain, and optic nerve arborization
  • localization of OLFM1 in the growth cones of neuronal cells suggests that it may play a role in axon growth and/or guidance
  • OLFM1 is a component of neuronal growth cones and is a novel soluble ligand of RTN4R, which regulates axonal outgrowth and axon bundle formation during brain development
  • is a highly expressed neuronal glycoprotein important for nervous system development
  • potential role for OLFM1 in clustering receptors to regulate signaling and sheds light on the conformation of several other olfactomedin domain family members
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    text neurogenesis
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • OLFM1 is a novel RTN4R ligand that modulates the functions of the RTN4R complex in axonal growth
  • binding of RTN4R and LINGO1 was similarly inhibited by OLFM1 coexpression
  • is an endogenous antagonist of myelin-associated axon growth inhibitors
  • cell & other
    REGULATION
    Other stabilized by calcium
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional       loss of function
    leads to defective olfaction and impaired female fertility (
    tumoral     --low  
    in primary Colorectal cancer samples compared to adjacent non-cancerous tissues
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • may be a valuable biomarker for CRC patients (pMID: 27555280)
  • Therapy target
    SystemTypeDisorderPubmed
    neurologyacquired 
    application of OLFM1 or stimulation of its expression may be used to facilitate neuronal growth after axonal damage or injury
    cancerdigestivecolon
    may be a valuable therapeutic target for Colorectal cancer patients
    ANIMAL & CELL MODELS
  • Olfm1(-/-) female mice were previously reported to have reduced fertility
  • olfactory system was both structurally and functionally disturbed by the mutation in the Olfm1 gene which may contribute to the neonatal death and loss of body weight of Olfm1 mutant