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FLASH GENE
Symbol OLFM1 contributors: mct - updated : 28-03-2018
HGNC name olfactomedin 1
HGNC id 17187
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
constitutional       loss of function
leads to defective olfaction and impaired female fertility (
tumoral     --low  
in primary Colorectal cancer samples compared to adjacent non-cancerous tissues
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
  • may be a valuable biomarker for CRC patients (pMID: 27555280)
  • Therapy target
    SystemTypeDisorderPubmed
    neurologyacquired 
    application of OLFM1 or stimulation of its expression may be used to facilitate neuronal growth after axonal damage or injury
    cancerdigestivecolon
    may be a valuable therapeutic target for Colorectal cancer patients
    ANIMAL & CELL MODELS
  • Olfm1(-/-) female mice were previously reported to have reduced fertility
  • olfactory system was both structurally and functionally disturbed by the mutation in the Olfm1 gene which may contribute to the neonatal death and loss of body weight of Olfm1 mutant