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FLASH GENE
Symbol OLFM1 contributors: mct - updated : 28-03-2018
HGNC name olfactomedin 1
HGNC id 17187
DNA
TYPE functioning gene
STRUCTURE 45.94 kb     2 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
6 - 2879 53 467 - 2016 27555280
OLFM-I1
4 splicing 1212 - 135 - 2016 27555280
OLFM-I2
- splicing 980 - 169 - 2016 27555280
- splicing 1300 55 485 - 2016 27555280
5 - 2502 - 458 - 2016 27555280
6 - 2791 - 485 - 2016 27555280
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain   highly Homo sapiens
 brainforebraincerebral cortex   Homo sapiens
 brainlimbic systemhippocampus   Homo sapiens
 gangliasensory gangliadorsal root   Mus musculus
 nervecranial nerveoptic nerve   Mus musculus
Olfactory (smell)olfactory bulb     Homo sapiens
Visualeyeretina    Mus musculus
 eyeanterior segmentcornea   Mus musculus
 eyesclera    Mus musculus
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Nervouscentral    Homo sapiens
Nervousperipherous    Homo sapiens
cells
SystemCellPubmedSpeciesStageRna symbol
Visualganglion cell Mus musculus
cell lineage
cell lines neuroblastoma cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal signal peptide
  • followed by a coiled-coil domain
  • an olfactomedin domain located in the C-terminal
  • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to murine Olfm1
    homolog to C.elegans R166.5
    Homologene
    FAMILY olfactomedin domain-containing proteins family
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    text
  • OLFM1 staining was equally strong in the endoplasmic reticulum and the growth cones
  • basic FUNCTION
  • playing a role in regulating the production of neural crest by the neural tube
  • participates in neural progenitor maintenance, cell death in brain, and optic nerve arborization
  • localization of OLFM1 in the growth cones of neuronal cells suggests that it may play a role in axon growth and/or guidance
  • OLFM1 is a component of neuronal growth cones and is a novel soluble ligand of RTN4R, which regulates axonal outgrowth and axon bundle formation during brain development
  • is a highly expressed neuronal glycoprotein important for nervous system development
  • potential role for OLFM1 in clustering receptors to regulate signaling and sheds light on the conformation of several other olfactomedin domain family members
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    text neurogenesis
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • OLFM1 is a novel RTN4R ligand that modulates the functions of the RTN4R complex in axonal growth
  • binding of RTN4R and LINGO1 was similarly inhibited by OLFM1 coexpression
  • is an endogenous antagonist of myelin-associated axon growth inhibitors
  • cell & other
    REGULATION
    Other stabilized by calcium
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional       loss of function
    leads to defective olfaction and impaired female fertility (
    tumoral     --low  
    in primary Colorectal cancer samples compared to adjacent non-cancerous tissues
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • may be a valuable biomarker for CRC patients (pMID: 27555280)
  • Therapy target
    SystemTypeDisorderPubmed
    neurologyacquired 
    application of OLFM1 or stimulation of its expression may be used to facilitate neuronal growth after axonal damage or injury
    cancerdigestivecolon
    may be a valuable therapeutic target for Colorectal cancer patients
    ANIMAL & CELL MODELS
  • Olfm1(-/-) female mice were previously reported to have reduced fertility
  • olfactory system was both structurally and functionally disturbed by the mutation in the Olfm1 gene which may contribute to the neonatal death and loss of body weight of Olfm1 mutant