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FLASH GENE
Symbol NT5C3A contributors: mct/npt - updated : 07-07-2014
HGNC name 5'-nucleotidase, cytosolic IIIA
HGNC id 17820
Corresponding disease
P5N1D hemolytic anemia due to P5N1 deficiency
Location 7p14.3      Physical location : -
Synonym name
  • pyrimidine 5'nucleotidase
  • uridine 5' monophosphate hydrolase 1
  • cytosolic 5'-nucleotidase III
  • lupin
    • Synonym symbol(s) NT5C3, PNI, PSN1, UMPH, P5N1, MGC27337, MGC87109, MGC87828, UMPH1, PN-I
    EC.number 3.1.3.5
    DNA
    TYPE functioning gene
    STRUCTURE 48.68 kb     10 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 1727 - 336 reticulocyte 2009 19623099
    an additional sequence overlapping exons 2 and 3
    10 - 1782 33 297 - 2009 19623099
    10 - 1846 34 297 - 2009 19623099
    11 - 1932 - 285 - 2009 19623099
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   moderately
    Digestiveliver   moderately
    Lymphoid/Immunelymph node   highly
    Nervousbrain   moderately
    Respiratorylung   moderately
    Urinarybladder   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow   
    Muscularstriatumskeletal highly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticerythrocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    HOMOLOGY
    Homologene
    FAMILY
  • pyrimidine 5'-nucleotidase family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • catalyzing the dephosphorylation of pyrimidine nucleoside monophosphate
  • transferring phophate groups between pyrimidine monophosphates and varioux pririmidine nucleosides
  • is responsible for selective degradation of pyrimidine 5prime-monoribonucleotides during maturation of reticulocytes to erythrocytes
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism purine/pyrimidine
    signaling
    pyrimidine metabolism
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Mg2+ dependent
    • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) P5N1D
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS