basic FUNCTION
| promoting neurite outgrowth and arborization |
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involved in perinecrotic hypoxia |
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plays multiple roles in the process of neural development and synaptic plasticity |
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protects neurons from apoptosis |
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regulates dendritic and axonal arbor growth and synaptic maturation |
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may function as a new factor required in re-establishment of neuronal network after the injury |
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extracellular ligand that promotes neurite growth, neuronal survival, and synaptic maturation |
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NRN1 and NRN1L promote neurite growth and neuronal survival with similar efficacy |
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perform similar cellular functions but may play distinct roles through their cell-type- and tissue-specific transcriptional regulation |
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plays an important role in promoting neuronal survival, differentiation, function, and repair |
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positive regulator of tumor angiogenesis |
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may play a positive role in angiogenesis, but act as a negative factor in tumorigenesis by generating poorly organized vessels |
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acts to stabilize active synapses on dendritic spines, resulting in selective spine and arbor stabilization and synaptic maturation, and synapse stabilization mediated by NRN1 is critical for efficient learning |
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activity-dependent protein involved in synaptic plasticity during brain development, a process that relies upon neuronal migration |
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novel function in promoting migration of neuronal cells and indicate that NRN1 levels impact on microtubule stability |