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FLASH GENE
Symbol NRN1 contributors: mct - updated : 12-06-2013
HGNC name neuritin 1
HGNC id 17972
Location 6p25.1      Physical location : 5.998.234 - 6.007.633
Synonym name
  • candidate plasticity gene 15
  • Synonym symbol(s) NRN, CPG15
    DNA
    TYPE functioning gene
    STRUCTURE 9.40 kb     3 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 2072 - 142 - 1997 9122250
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Digestivesalivary gland   highly
    Endocrineneuroendocrinepituitary  highly
    Nervousbrainforebraincerebral cortex highly Homo sapiens
     brainlimbic systemhippocampus highly Homo sapiens
     brain     Homo sapiens
     nerve   predominantly Homo sapiens
    Visualeyeretina  moderately Homo sapiens
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone  highly
    Nervousperipherous  predominantly Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousneuron Homo sapiens
    Visualganglion cell Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a 27 amino acids signal peptide at its N terminus (2.97 kDa)
  • a consensus cleavage signal found in glycosylphoshatidylinositol (GPI)-anchored proteins
  • a 27 amino acids GPI signal peptide at its C terminus
  • mono polymer homomer , heteromer , dimer
    isoforms Precursor a 115 amino acids mature peptide (12.4 kDa)
    HOMOLOGY
    interspecies homolog to murine Nrn1 (97.18 pc)
    intraspecies paralog to NRN1L
    Homologene
    FAMILY
  • neurotrophic factor family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane,junction
    text
  • attached to the extracellular membrane by a glycosylphosphatidylinositol (GPI) anchor
  • basic FUNCTION
  • promoting neurite outgrowth and arborization
  • involved in perinecrotic hypoxia
  • plays multiple roles in the process of neural development and synaptic plasticity
  • protects neurons from apoptosis
  • regulates dendritic and axonal arbor growth and synaptic maturation
  • may function as a new factor required in re-establishment of neuronal network after the injury
  • extracellular ligand that promotes neurite growth, neuronal survival, and synaptic maturation
  • NRN1 and NRN1L promote neurite growth and neuronal survival with similar efficacy
  • perform similar cellular functions but may play distinct roles through their cell-type- and tissue-specific transcriptional regulation
  • plays an important role in promoting neuronal survival, differentiation, function, and repair
  • positive regulator of tumor angiogenesis
  • may play a positive role in angiogenesis, but act as a negative factor in tumorigenesis by generating poorly organized vessels
  • acts to stabilize active synapses on dendritic spines, resulting in selective spine and arbor stabilization and synaptic maturation, and synapse stabilization mediated by NRN1 is critical for efficient learning
  • activity-dependent protein involved in synaptic plasticity during brain development, a process that relies upon neuronal migration
  • novel function in promoting migration of neuronal cells and indicate that NRN1 levels impact on microtubule stability
  • CELLULAR PROCESS cell life, differentiation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component NRN1 and NRN1L form homodimers and heterodimers with each other
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    induced by neural activity and neurotrophins
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in astrocytoma, which may be an important factor in tumorigenesis and progression of astrocytoma (
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerangiogenesis 
    may serve as a potential target for anti-angiogenic therapy
    ANIMAL & CELL MODELS
  • cpg15 knockout mice require more trails to learn, but once they learn, memories are retained