Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol NRN1 contributors: mct - updated : 12-06-2013
HGNC name neuritin 1
HGNC id 17972
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
3 - 2072 - 142 - 1997 9122250
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Digestivesalivary gland   highly
Endocrineneuroendocrinepituitary  highly
Nervousbrainforebraincerebral cortex highly Homo sapiens
 brainlimbic systemhippocampus highly Homo sapiens
 brain     Homo sapiens
 nerve   predominantly Homo sapiens
Visualeyeretina  moderately Homo sapiens
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectivebone  highly
Nervousperipherous  predominantly Homo sapiens
cells
SystemCellPubmedSpeciesStageRna symbol
Nervousneuron Homo sapiens
Visualganglion cell Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a 27 amino acids signal peptide at its N terminus (2.97 kDa)
  • a consensus cleavage signal found in glycosylphoshatidylinositol (GPI)-anchored proteins
  • a 27 amino acids GPI signal peptide at its C terminus
  • mono polymer homomer , heteromer , dimer
    isoforms Precursor a 115 amino acids mature peptide (12.4 kDa)
    HOMOLOGY
    interspecies homolog to murine Nrn1 (97.18 pc)
    intraspecies paralog to NRN1L
    Homologene
    FAMILY
  • neurotrophic factor family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane,junction
    text
  • attached to the extracellular membrane by a glycosylphosphatidylinositol (GPI) anchor
  • basic FUNCTION
  • promoting neurite outgrowth and arborization
  • involved in perinecrotic hypoxia
  • plays multiple roles in the process of neural development and synaptic plasticity
  • protects neurons from apoptosis
  • regulates dendritic and axonal arbor growth and synaptic maturation
  • may function as a new factor required in re-establishment of neuronal network after the injury
  • extracellular ligand that promotes neurite growth, neuronal survival, and synaptic maturation
  • NRN1 and NRN1L promote neurite growth and neuronal survival with similar efficacy
  • perform similar cellular functions but may play distinct roles through their cell-type- and tissue-specific transcriptional regulation
  • plays an important role in promoting neuronal survival, differentiation, function, and repair
  • positive regulator of tumor angiogenesis
  • may play a positive role in angiogenesis, but act as a negative factor in tumorigenesis by generating poorly organized vessels
  • acts to stabilize active synapses on dendritic spines, resulting in selective spine and arbor stabilization and synaptic maturation, and synapse stabilization mediated by NRN1 is critical for efficient learning
  • activity-dependent protein involved in synaptic plasticity during brain development, a process that relies upon neuronal migration
  • novel function in promoting migration of neuronal cells and indicate that NRN1 levels impact on microtubule stability
  • CELLULAR PROCESS cell life, differentiation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component NRN1 and NRN1L form homodimers and heterodimers with each other
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    induced by neural activity and neurotrophins
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in astrocytoma, which may be an important factor in tumorigenesis and progression of astrocytoma (
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerangiogenesis 
    may serve as a potential target for anti-angiogenic therapy
    ANIMAL & CELL MODELS
  • cpg15 knockout mice require more trails to learn, but once they learn, memories are retained