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FLASH GENE
Symbol NRN1 contributors: mct - updated : 12-06-2013
HGNC name neuritin 1
HGNC id 17972
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a 27 amino acids signal peptide at its N terminus (2.97 kDa)
  • a consensus cleavage signal found in glycosylphoshatidylinositol (GPI)-anchored proteins
  • a 27 amino acids GPI signal peptide at its C terminus
  • mono polymer homomer , heteromer , dimer
    isoforms Precursor a 115 amino acids mature peptide (12.4 kDa)
    HOMOLOGY
    interspecies homolog to murine Nrn1 (97.18 pc)
    intraspecies paralog to NRN1L
    Homologene
    FAMILY
  • neurotrophic factor family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane,junction
    text
  • attached to the extracellular membrane by a glycosylphosphatidylinositol (GPI) anchor
  • basic FUNCTION
  • promoting neurite outgrowth and arborization
  • involved in perinecrotic hypoxia
  • plays multiple roles in the process of neural development and synaptic plasticity
  • protects neurons from apoptosis
  • regulates dendritic and axonal arbor growth and synaptic maturation
  • may function as a new factor required in re-establishment of neuronal network after the injury
  • extracellular ligand that promotes neurite growth, neuronal survival, and synaptic maturation
  • NRN1 and NRN1L promote neurite growth and neuronal survival with similar efficacy
  • perform similar cellular functions but may play distinct roles through their cell-type- and tissue-specific transcriptional regulation
  • plays an important role in promoting neuronal survival, differentiation, function, and repair
  • positive regulator of tumor angiogenesis
  • may play a positive role in angiogenesis, but act as a negative factor in tumorigenesis by generating poorly organized vessels
  • acts to stabilize active synapses on dendritic spines, resulting in selective spine and arbor stabilization and synaptic maturation, and synapse stabilization mediated by NRN1 is critical for efficient learning
  • activity-dependent protein involved in synaptic plasticity during brain development, a process that relies upon neuronal migration
  • novel function in promoting migration of neuronal cells and indicate that NRN1 levels impact on microtubule stability
  • CELLULAR PROCESS cell life, differentiation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component NRN1 and NRN1L form homodimers and heterodimers with each other
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    induced by neural activity and neurotrophins
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in astrocytoma, which may be an important factor in tumorigenesis and progression of astrocytoma (
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerangiogenesis 
    may serve as a potential target for anti-angiogenic therapy
    ANIMAL & CELL MODELS
  • cpg15 knockout mice require more trails to learn, but once they learn, memories are retained