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FLASH GENE
Symbol NETO1 contributors: mct - updated : 20-12-2014
HGNC name neuropilin (NRP) and tolloid (TLL)-like 1
HGNC id 13823
Location 18q22.3      Physical location : 70.414.786 - 70.534.810
Synonym symbol(s) BCTL1, BTCL1
DNA
TYPE functioning gene
STRUCTURE 126.02 kb     13 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
NCAG1 18q22.1 NCAG1 LOC390862 18 similar to SECIS-binding protein 2 LOC342800 18q22.1 similar to ATP synthase, H+ transporting, mitochondrial F0 complex, subunit b, isoform 1 LOC390863 18 similar to aldo-keto reductase family 1, member B10; aldose reductase-like 1; aldo-keto reductase family 1, member B11 (aldose reductase-like); aldose reductase-like peptide; aldose reductase-related protein; small intestine reducta FLJ20793 18q22 FLJ20793 protein FLJ23594 18q22.1 hypothetical protein FLJ23594 MGC20785 18q22.2 hypothetical protein MGC20785 CD226 18q22.3 CD226 antigen RTTN 18q22.1 rotatin SOCS4 18q22.2 suppressor of cytokine signaling 4 LOC339306 18q22.2 hypothetical LOC339306 LOC342808 18q22.2 similar to 40S ribosomal protein S2 CBLN2 18q23 cerebellin 2 precursor NETO1 18q22.2 neuropilin (NRP) and tolloid (TLL)-like 1 LOC388481 18 LOC388481 FBXO15 18q22.3 F-box only protein 15 HSPC154 18q22.3 HSPC154 protein CYB5 18q23 cytochrome b-5 FAUP1 18 FBR-MuSV-associated ubiquitously expressed (fox derived) pseudogene 1 LOC125704 18q22.3 similar to hypothetical protein B230399E16 CN2 18q22.3 cytosolic nonspecific dipeptidase (EC 3.4.13.18) CN1 18q22.3 carnosinase 1 ZNF407 18q23 zinc finger protein 407 MGC45594 18q22.3 hypothetical protein MGC45594 SDCCAG33 18q22.3 serologically defined colon cancer antigen 33 LOC388482 18 LOC388482 LOC284275 18q23 hypothetical LOC284275 KIAA0222 18q23 hypothetical LOC284275 ZNF236 18q22-q23 zinc finger protein 236 MBP 18q23 myelin basic protein LOC388483 18 LOC388483 GALR1 18q23 galanin receptor 1 LOC390864 18 similar to amino acid feature: Rod protein domain, aa 266 .. 468; amino acid feature: globular protein domain, aa 32 .. 265 LOC125595 18q23 hypothetical LOC125595 LOC390865 18 similar to hypothetical protein LOC390866 18 LOC390866 LOC390867 18 similar to Splicing factor 3A subunit 2 (Spliceosome associated protein 62) (SAP 62) (SF3a66)
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
12 - 2513 60.2 533 - 2003 12810072
identical to isoform 2
- - 1849 - 156 soluble isoform 2003 12810072
  • contains only one CUB domain and lacks the LDLa repeat, the predicted transmembrane domain, and the FXNPXY-like motif
  • 11 - 2328 - 532 - 2003 12810072
    identical to isoform 3
    EXPRESSION
    Rna function mRNAs were observed restrictively in brain throughout embryonic and postnatal stages, uniquely in the pontine nucleus and subplate, which are required for establishing the neuronal circuit formation
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbraindiencephalonhypothalamus   Homo sapiens
     brainlimbic systemhippocampus   Homo sapiens
    Visualeyeretina   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two extracellular CUB domains followed by a low-density lipoprotein class A (LDLa) domain
  • a transmembrane domain
  • an intracellular FXNPXY-like motif, which has been shown in other proteins to be essential for the internalization of clathrin coated pits during endocytosis
  • isoforms Precursor
    HOMOLOGY
    interspecies homolog to murine Neto1
    Homologene
    FAMILY
    CATEGORY signaling
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    basic FUNCTION
  • may be involved in intracellular signaling pathway
  • having roles during development of the central nervous system
  • regulates NMDA receptor-dependent synaptic plasticity and cognition
  • have marked effects on receptor properties, increasing further the potential diversity of KAR (Kainate receptor) functional properties
  • by regulating kainate receptor excitatory postsynaptic current kinetics, NETO1 can control synaptic temporal summation, spike generation and fidelity
  • the ability of NETO1 to regulate both NMDARs and kainate receptors reveals a unique dual role in controlling synaptic transmission by serving as an auxiliary protein for these two classes of ionotropic glutamate receptors in a synapse-specific fashion
  • NETO1, and NETO2 are auxiliary subunits that determine key properties of native kainate receptors
  • NETO1, and NETO2 transmembrane proteins alter the trafficking, channel kinetics, and pharmacology of the receptors in a subunit-dependent manner
  • NETO1 and NETO2 auxiliary subunits coassemble with NMDA receptors (NMDARs) and kainate receptors (KARs) to modulate their function
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of the NMDAR complex critical for maintaining the abundance of NR2A-containing NMDARs in the postsynaptic density
  • component of APP/NMDAR trafficking complexes
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • in neurons, kainate receptors can associate with the auxiliary subunits NETO1 or NETO2
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to autism
    Variant & Polymorphism other
  • region of hemizygosity including TCF4, NETO1, and FBXO15 significantly more likely to exhibit autistic-like behaviors
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • deficits in LTP, learning, and memory in Neto1-null mice were rescued by the ampakine CX546 at doses without effect in wild-type