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FLASH GENE
Symbol NETO1 contributors: mct - updated : 20-12-2014
HGNC name neuropilin (NRP) and tolloid (TLL)-like 1
HGNC id 13823
EXPRESSION
Rna function mRNAs were observed restrictively in brain throughout embryonic and postnatal stages, uniquely in the pontine nucleus and subplate, which are required for establishing the neuronal circuit formation
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbraindiencephalonhypothalamus   Homo sapiens
 brainlimbic systemhippocampus   Homo sapiens
Visualeyeretina   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two extracellular CUB domains followed by a low-density lipoprotein class A (LDLa) domain
  • a transmembrane domain
  • an intracellular FXNPXY-like motif, which has been shown in other proteins to be essential for the internalization of clathrin coated pits during endocytosis
    • isoforms Precursor
    HOMOLOGY
    interspecies homolog to murine Neto1
    Homologene
    FAMILY
    CATEGORY signaling
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    basic FUNCTION
  • may be involved in intracellular signaling pathway
  • having roles during development of the central nervous system
  • regulates NMDA receptor-dependent synaptic plasticity and cognition
  • have marked effects on receptor properties, increasing further the potential diversity of KAR (Kainate receptor) functional properties
  • by regulating kainate receptor excitatory postsynaptic current kinetics, NETO1 can control synaptic temporal summation, spike generation and fidelity
  • the ability of NETO1 to regulate both NMDARs and kainate receptors reveals a unique dual role in controlling synaptic transmission by serving as an auxiliary protein for these two classes of ionotropic glutamate receptors in a synapse-specific fashion
  • NETO1, and NETO2 are auxiliary subunits that determine key properties of native kainate receptors
  • NETO1, and NETO2 transmembrane proteins alter the trafficking, channel kinetics, and pharmacology of the receptors in a subunit-dependent manner
  • NETO1 and NETO2 auxiliary subunits coassemble with NMDA receptors (NMDARs) and kainate receptors (KARs) to modulate their function
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of the NMDAR complex critical for maintaining the abundance of NR2A-containing NMDARs in the postsynaptic density
  • component of APP/NMDAR trafficking complexes
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • in neurons, kainate receptors can associate with the auxiliary subunits NETO1 or NETO2
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to autism
    Variant & Polymorphism other
  • region of hemizygosity including TCF4, NETO1, and FBXO15 significantly more likely to exhibit autistic-like behaviors
    • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • deficits in LTP, learning, and memory in Neto1-null mice were rescued by the ampakine CX546 at doses without effect in wild-type