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FLASH GENE
Symbol NETO1 contributors: mct - updated : 20-12-2014
HGNC name neuropilin (NRP) and tolloid (TLL)-like 1
HGNC id 13823
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two extracellular CUB domains followed by a low-density lipoprotein class A (LDLa) domain
  • a transmembrane domain
  • an intracellular FXNPXY-like motif, which has been shown in other proteins to be essential for the internalization of clathrin coated pits during endocytosis
    • isoforms Precursor
    HOMOLOGY
    interspecies homolog to murine Neto1
    Homologene
    FAMILY
    CATEGORY signaling
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    basic FUNCTION
  • may be involved in intracellular signaling pathway
  • having roles during development of the central nervous system
  • regulates NMDA receptor-dependent synaptic plasticity and cognition
  • have marked effects on receptor properties, increasing further the potential diversity of KAR (Kainate receptor) functional properties
  • by regulating kainate receptor excitatory postsynaptic current kinetics, NETO1 can control synaptic temporal summation, spike generation and fidelity
  • the ability of NETO1 to regulate both NMDARs and kainate receptors reveals a unique dual role in controlling synaptic transmission by serving as an auxiliary protein for these two classes of ionotropic glutamate receptors in a synapse-specific fashion
  • NETO1, and NETO2 are auxiliary subunits that determine key properties of native kainate receptors
  • NETO1, and NETO2 transmembrane proteins alter the trafficking, channel kinetics, and pharmacology of the receptors in a subunit-dependent manner
  • NETO1 and NETO2 auxiliary subunits coassemble with NMDA receptors (NMDARs) and kainate receptors (KARs) to modulate their function
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of the NMDAR complex critical for maintaining the abundance of NR2A-containing NMDARs in the postsynaptic density
  • component of APP/NMDAR trafficking complexes
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • in neurons, kainate receptors can associate with the auxiliary subunits NETO1 or NETO2
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to autism
    Variant & Polymorphism other
  • region of hemizygosity including TCF4, NETO1, and FBXO15 significantly more likely to exhibit autistic-like behaviors
    • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • deficits in LTP, learning, and memory in Neto1-null mice were rescued by the ampakine CX546 at doses without effect in wild-type