Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol NDNF contributors: mct - updated : 15-01-2020
HGNC name neuron derived neurotrophic factor
HGNC id 26256
Corresponding disease
KAL9 Kallmann syndrome 9
Location 4q27      Physical location : -
Genatlas name epidermacan
Synonym name
  • hypothetical protein LOC79625
  • fibronectin type-III domain-containing protein C4orf31
  • chromosome 4 open reading frame 31
    • Synonym symbol(s) FLJ23191, C4orf31, NORD
    DNA
    TYPE functioning gene
    STRUCTURE 43.24 kb     4 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 2902 64.5 568 - 2014 24706764
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrainlimbic systemhippocampus   Homo sapiensFetal
     brainforebraincerebral cortex   Homo sapiensFetal
     brainhindbraincerebellum   Homo sapiensFetal
    Olfactory (smell)olfactory bulb     Homo sapiens
    Respiratorynosenasal septumvomer   Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousmitral cell Homo sapiensFetal
    Nervousneuron Homo sapiensFetal
    NervousPurkinje cell Homo sapiensFetal
    Nervouspyramidal cell Homo sapiensFetal
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • fibronectin type-III domains, FN3 domains that are critical for binding to heparan sulfate proteoglycans
    • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • is a secreted neurotrophic factor that can promote neuron migration, growth, and survival, as well as neurite outgrowth
  • acts as an endogenous modulator that promotes endothelial cell function and ischemia-induced revascularization through eNOS-dependent mechanisms
  • could be a new factor to rejuvenate aged stem cells and improve their capability to repair the aged heart after injury
  • glycosylated, disulfide-bonded secretory protein 1)
  • important regulator of epithelial-mesenchymal transition (EMT) in Renal cell carcinoma progression 1)
  • role of NDNF in GNRH neuron development, and in the migration of GNRH neurons
  • NDNF acts as a chemorepellent molecule on GNRH cell migration
  • possible role of NDNF in GNRH neuron biology beyond embryonic development
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • NDNF could interact with FGF8, a well-known morphogen acting during early developmental stages on the fate specification of GNRH neurons in the olfactory placode (PMID;:
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) KAL9
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in Renal cell carcinoma (RCC) cell lines and RCC tissues
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancermetastases 
    may represent a novel promising target for antimetastatic therapy
    miscelleaneousvascularischemic injury
    therapeutic target for the manipulation of ischemic vascular disorders.
    neurologyacquired 
    useful in the treatment of neuronal degeneration diseases and nerve injuries
    ANIMAL & CELL MODELS