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FLASH GENE
Symbol NDNF contributors: mct - updated : 15-01-2020
HGNC name neuron derived neurotrophic factor
HGNC id 26256
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • fibronectin type-III domains, FN3 domains that are critical for binding to heparan sulfate proteoglycans
    • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • is a secreted neurotrophic factor that can promote neuron migration, growth, and survival, as well as neurite outgrowth
  • acts as an endogenous modulator that promotes endothelial cell function and ischemia-induced revascularization through eNOS-dependent mechanisms
  • could be a new factor to rejuvenate aged stem cells and improve their capability to repair the aged heart after injury
  • glycosylated, disulfide-bonded secretory protein 1)
  • important regulator of epithelial-mesenchymal transition (EMT) in Renal cell carcinoma progression 1)
  • role of NDNF in GNRH neuron development, and in the migration of GNRH neurons
  • NDNF acts as a chemorepellent molecule on GNRH cell migration
  • possible role of NDNF in GNRH neuron biology beyond embryonic development
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • NDNF could interact with FGF8, a well-known morphogen acting during early developmental stages on the fate specification of GNRH neurons in the olfactory placode (PMID;:
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) KAL9
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in Renal cell carcinoma (RCC) cell lines and RCC tissues
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancermetastases 
    may represent a novel promising target for antimetastatic therapy
    miscelleaneousvascularischemic injury
    therapeutic target for the manipulation of ischemic vascular disorders.
    neurologyacquired 
    useful in the treatment of neuronal degeneration diseases and nerve injuries
    ANIMAL & CELL MODELS