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FLASH GENE

Symbol

NDNF

contributors: mct - updated : 15-01-2020

HGNC name	neuron derived neurotrophic factor
HGNC id	26256

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_024574 4 - 2902 NP_078850 64.5 568 - 2014 24706764

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain limbic system hippocampus     Homo sapiens Fetal   brain forebrain cerebral cortex     Homo sapiens Fetal   brain hindbrain cerebellum     Homo sapiens Fetal Olfactory (smell) olfactory bulb         Homo sapiens Respiratory nose nasal septum vomer     Homo sapiens

cells

System Cell Pubmed Species Stage Rna symbol Nervous mitral cell Homo sapiens Fetal Nervous neuron Homo sapiens Fetal Nervous Purkinje cell Homo sapiens Fetal Nervous pyramidal cell Homo sapiens Fetal

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

fibronectin type-III domains, FN3 domains that are critical for binding to heparan sulfate proteoglycans

HOMOLOGY

Homologene

FAMILY

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION

extracellular

basic FUNCTION	is a secreted neurotrophic factor that can promote neuron migration, growth, and survival, as well as neurite outgrowth
	acts as an endogenous modulator that promotes endothelial cell function and ischemia-induced revascularization through eNOS-dependent mechanisms
	could be a new factor to rejuvenate aged stem cells and improve their capability to repair the aged heart after injury
	glycosylated, disulfide-bonded secretory protein 1)
	important regulator of epithelial-mesenchymal transition (EMT) in Renal cell carcinoma progression 1)
	role of NDNF in GNRH neuron development, and in the migration of GNRH neurons
	NDNF acts as a chemorepellent molecule on GNRH cell migration
	possible role of NDNF in GNRH neuron biology beyond embryonic development

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

NDNF could interact with FGF8, a well-known morphogen acting during early developmental stages on the fate specification of GNRH neurons in the olfactory placode (PMID;:

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

KAL9

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   in Renal cell carcinoma (RCC) cell lines and RCC tissues

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer metastases   may represent a novel promising target for antimetastatic therapy miscelleaneous vascular ischemic injury therapeutic target for the manipulation of ischemic vascular disorders. neurology acquired   useful in the treatment of neuronal degeneration diseases and nerve injuries

ANIMAL & CELL MODELS