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FLASH GENE
Symbol NCL contributors: sge/npt/pgu - updated : 25-05-2015
HGNC name nucleolin
HGNC id 7667
Location 2q37.1      Physical location : 232.319.459 - 232.329.205
Synonym name
  • DNA helicase IV
  • protein C23
  • Synonym symbol(s) HDHIV, C23, FLJ45706
    DNA
    TYPE functioning gene
    SPECIAL FEATURE
    text RNU 20 embedded in one intron, same strand
    STRUCTURE 9.75 kb     14 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Binding site
    text structure RNA binding site
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC93349 2q37.1 hypothetical protein BC004921 SP100 2q37.1 nuclear antigen SP100 HMG1L3 2q35 high-mobility group (nonhistone chromosomal) protein 1-like 3 LOC389079 2 similar to tropomyosin 3 LOC391489 2 similar to LOC93349 protein MO25 2q37.1 MO25 protein ITM2C 2q37 integral membrane protein 2C GPR55 2q37 G protein-coupled receptor 55 TSARG1 LOC389080 2 LOC389080 PSMD1 2q37.1-q37.2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 HTR2B 2q36.3-q37.1 5-hydroxytryptamine (serotonin) receptor 2B FLJ12584 2q37.1 hypothetical protein FLJ12584 FLJ23510 2q37.1 hypothetical protein FLJ23510 LOC389081 2 LOC389081 B3GNT7 2q36.1 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7 LOC389082 2 similar to archease NCL 2q12-qter nucleolin MGC43122 2q37.1 hypothetical protein MGC43122 GPR66 2q37.1 G protein-coupled receptor 66 LOC391490 2 similar to 60S ribosomal protein L23a MGC35154 2q37.1 hypothetical protein MGC35154 MGC4771 2q37.1 hypothetical protein MGC4771 PTMA 2q36-q36 prothymosin, alpha (gene sequence 28) PDE6D 2q36 phosphodiesterase 6D, cGMP-specific, rod, delta COPS7B 2q36.2 COP9 constitutive photomorphogenic homolog subunit 7B (Arabidopsis) LOC391491 2 similar to guanidinoacetate methyltransferase; GAMT NPPC 2q24-qter natriuretic peptide precursor C MGC42174 2q37.1 hypothetical protein MGC42174 ALPP 2q37.1 alkaline phosphatase, placental (Regan isozyme) ALPPL2 2q37 alkaline phosphatase, placental-like 2 LOC391492 2 similar to xce ALPI 2q37.1 alkaline phosphatase, intestinal ECEL1 2q36-q37 endothelin converting enzyme-like 1 LOC389083 2 similar to enterokinase CHRND 2q37 cholinergic receptor, nicotinic, delta polypeptide
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    14 - 2732 - 710 - 2001 11736641
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon highly
     intestinesmall intestine  highly
    Endocrinepancreas    
    Lymphoid/Immunespleen    
     thymus    
    Nervousbrain    
    Reproductivefemale systembreastmammary gland highly
    Respiratorylung    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES acid
    STRUCTURE
    motifs/domains
  • RNA binding domains 3 and 4, as well as the arginine-glycine-glycine (RGG) domain, are required to repress MYC transcription
  • RNA-binding domain of NCL participates in binding to TP53 mRNA, is required for both NCL dimerization and NCL-mediated translational repression, and is the domain of NCL that interacts with RPL26
  • four RNA recognition motif (RRM)
  • C-terminal RGG domain of nucleolin is required for interaction with RAD50
  • conjugated PhosphoP
    HOMOLOGY
    interspecies homolog to murine Ncl
    intraspecies homolog to PABPC4
    Homologene
    FAMILY
    CATEGORY RNA associated , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic,ribosome
    intracellular,nucleus,nucleolus
    basic FUNCTION
  • major multifunctional nucleolar phosphoprotein characterized by unique tripartite function within each domain
  • performing activities i.e. a specific DNA helicase and DNA-dependent ATPase
  • involved in binding of glucocorticoid receptor in the nucleolus
  • playing a role in posttranscriptional control of MMP9 expression
  • general role for nucleolin in gene regulation and it is a novel factor involved in regulation of KLF2 expression
  • may be involved in the dynamics of human papillomavirus genome in cells (
  • may induce the MYC G-quadruplex formation that functions as a transcriptional repressor for MYC (Gonzalez 2009)
  • major multifunctional nucleolar phosphoprotein characterized by unique tripartite function within each domain
  • performing activities i.e. a specific DNA helicase and DNA-dependent ATPase
  • involved in binding of glucocorticoid receptor in the nucleolus
  • may induce the MYC G-quadruplex formation that functions as a transcriptional repressor for MYC
  • playing a role in posttranscriptional control of MMP9 expression
  • may be involved in the dynamics of human papillomavirus genome in cells (
  • plays important roles in chromatin structure, rDNA transcription, rRNA maturation, nucleocytoplasmic transport, and ribosome assembly
  • important negative regulatory role for nucleolin in the apoptosis of endothelial cells, likely involving the BAX pathway
  • an essential downstream effecter of Hsp70 in the protection of cardiomyocytes against oxidative stress-induced apoptosis
  • major nucleolar protein that has been shown to be overexpressed in rapidly dividing cells and plays an essential role in cell proliferation and survival
  • major nucleolar protein that has been shown to be overexpressed in rapidly dividing cells and plays an essential role in cell proliferation and survival
  • most abundant nucleolar phosphoprotein of eukaryotic cells, is known primarily for its role in ribosome biogenesis and cell proliferation
  • HNRNPL and nucleolin bind LINE-1 RNA and function as host factors to modulate retrotransposition
  • is required for nucleosome disruption surrounding a double-strand break (DSB)
  • plays a critical role in DNA repair by promoting partial nucleosome disruption and permitting subsequent recruitment of DNA repair factors
  • is a chromatin-remodeling factor that facilitates nucleosome disassembly and efficient DSB repair
  • CELLULAR PROCESS cell cycle, division
    cell life, proliferation/growth
    nucleotide, chromatin organization, remodeling
    nucleotide, replication
    nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    text RNA processing, modification, exponentially growing cells
    PATHWAY
    metabolism
    signaling
    a component a component of B cell specific transcription factor,involved in ribosome biogenesis, cytokinesis, nucleogenesis, cell proliferation and growth, chromatin remodeling etc...
    INTERACTION
    DNA binding to human papillomavirus type 16 DNA (
    RNA
  • binding (sequence specific)
  • HMGB2, YY1 (to mediate transcriptional derepression of FSHD gene resulting in disease)
  • small molecule
    protein
  • binding to MYB transcription factors and to SMN1
  • binding to selectin (ligand of L-selectin)
  • can function as a repressor of MYC transcription by binding to and stabilizing the formation of a G-quadruplex structure in a region of the MYC promoter
  • binding partner of NVL
  • RPL26 and NCL interact with each other and with a double-stranded RNA structure in TP53 mRNA to regulate TP53 translation after stress
  • RPL26 likely interacts with NCL and binds to TP53 mRNA in the nucleus
  • HSPA8 is a prerequisite for the surface translocation and angiogenic function of NCL, which suggests strategies to target both HSPA8 and NCL for more effective antiangiogenic therapies
  • interacts with RAD50 via its arginine-glycine rich domain and is recruited to DSBs rapidly in an MRE11-NBS1-RAD50 complex-dependent manner
  • nucleolin (NCL), a nuclear multifunctional protein, is an interaction partner of FGF1, and NCL-FGF1 interaction is critical for the intranuclear phosphorylation of FGF1 by PRKCD and thereby the regulation of nuclear export of FGF1
  • NCL phosphorylation offers specificity to its protein-protein, protein-RNA interactions, resulting in the PARN deadenylase regulation, and hence gene expression, during cellular stress responses
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    associated with better prognosis in patients with stage II pancreatic ductal adenocarcinoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • an independent prognostic marker for better survival for patients with stage II pancreatic ductal adenocarcinoma (
  • Therapy target
    ANIMAL & CELL MODELS