Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol NCL contributors: sge/npt/pgu - updated : 25-05-2015
HGNC name nucleolin
HGNC id 7667
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
14 - 2732 - 710 - 2001 11736641
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinelarge intestinecolon highly
 intestinesmall intestine  highly
Endocrinepancreas    
Lymphoid/Immunespleen    
 thymus    
Nervousbrain    
Reproductivefemale systembreastmammary gland highly
Respiratorylung    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoieticbone marrow   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES acid
STRUCTURE
motifs/domains
  • RNA binding domains 3 and 4, as well as the arginine-glycine-glycine (RGG) domain, are required to repress MYC transcription
  • RNA-binding domain of NCL participates in binding to TP53 mRNA, is required for both NCL dimerization and NCL-mediated translational repression, and is the domain of NCL that interacts with RPL26
  • four RNA recognition motif (RRM)
  • C-terminal RGG domain of nucleolin is required for interaction with RAD50
  • conjugated PhosphoP
    HOMOLOGY
    interspecies homolog to murine Ncl
    intraspecies homolog to PABPC4
    Homologene
    FAMILY
    CATEGORY RNA associated , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic,ribosome
    intracellular,nucleus,nucleolus
    basic FUNCTION
  • major multifunctional nucleolar phosphoprotein characterized by unique tripartite function within each domain
  • performing activities i.e. a specific DNA helicase and DNA-dependent ATPase
  • involved in binding of glucocorticoid receptor in the nucleolus
  • playing a role in posttranscriptional control of MMP9 expression
  • general role for nucleolin in gene regulation and it is a novel factor involved in regulation of KLF2 expression
  • may be involved in the dynamics of human papillomavirus genome in cells (
  • may induce the MYC G-quadruplex formation that functions as a transcriptional repressor for MYC (Gonzalez 2009)
  • major multifunctional nucleolar phosphoprotein characterized by unique tripartite function within each domain
  • performing activities i.e. a specific DNA helicase and DNA-dependent ATPase
  • involved in binding of glucocorticoid receptor in the nucleolus
  • may induce the MYC G-quadruplex formation that functions as a transcriptional repressor for MYC
  • playing a role in posttranscriptional control of MMP9 expression
  • may be involved in the dynamics of human papillomavirus genome in cells (
  • plays important roles in chromatin structure, rDNA transcription, rRNA maturation, nucleocytoplasmic transport, and ribosome assembly
  • important negative regulatory role for nucleolin in the apoptosis of endothelial cells, likely involving the BAX pathway
  • an essential downstream effecter of Hsp70 in the protection of cardiomyocytes against oxidative stress-induced apoptosis
  • major nucleolar protein that has been shown to be overexpressed in rapidly dividing cells and plays an essential role in cell proliferation and survival
  • major nucleolar protein that has been shown to be overexpressed in rapidly dividing cells and plays an essential role in cell proliferation and survival
  • most abundant nucleolar phosphoprotein of eukaryotic cells, is known primarily for its role in ribosome biogenesis and cell proliferation
  • HNRNPL and nucleolin bind LINE-1 RNA and function as host factors to modulate retrotransposition
  • is required for nucleosome disruption surrounding a double-strand break (DSB)
  • plays a critical role in DNA repair by promoting partial nucleosome disruption and permitting subsequent recruitment of DNA repair factors
  • is a chromatin-remodeling factor that facilitates nucleosome disassembly and efficient DSB repair
  • CELLULAR PROCESS cell cycle, division
    cell life, proliferation/growth
    nucleotide, chromatin organization, remodeling
    nucleotide, replication
    nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    text RNA processing, modification, exponentially growing cells
    PATHWAY
    metabolism
    signaling
    a component a component of B cell specific transcription factor,involved in ribosome biogenesis, cytokinesis, nucleogenesis, cell proliferation and growth, chromatin remodeling etc...
    INTERACTION
    DNA binding to human papillomavirus type 16 DNA (
    RNA
  • binding (sequence specific)
  • HMGB2, YY1 (to mediate transcriptional derepression of FSHD gene resulting in disease)
  • small molecule
    protein
  • binding to MYB transcription factors and to SMN1
  • binding to selectin (ligand of L-selectin)
  • nucleolin is recruited to acetylated IRF2, thereby contributing to gene regulation crucial for the control of cell growth
  • can function as a repressor of MYC transcription by binding to and stabilizing the formation of a G-quadruplex structure in a region of the MYC promoter
  • binding partner of NVL
  • RPL26 and NCL interact with each other and with a double-stranded RNA structure in TP53 mRNA to regulate TP53 translation after stress
  • RPL26 likely interacts with NCL and binds to TP53 mRNA in the nucleus
  • HSPA8 is a prerequisite for the surface translocation and angiogenic function of NCL, which suggests strategies to target both HSPA8 and NCL for more effective antiangiogenic therapies
  • interacts with RAD50 via its arginine-glycine rich domain and is recruited to DSBs rapidly in an MRE11-NBS1-RAD50 complex-dependent manner
  • nucleolin (NCL), a nuclear multifunctional protein, is an interaction partner of FGF1, and NCL-FGF1 interaction is critical for the intranuclear phosphorylation of FGF1 by PRKCD and thereby the regulation of nuclear export of FGF1
  • NCL phosphorylation offers specificity to its protein-protein, protein-RNA interactions, resulting in the PARN deadenylase regulation, and hence gene expression, during cellular stress responses
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    associated with better prognosis in patients with stage II pancreatic ductal adenocarcinoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • an independent prognostic marker for better survival for patients with stage II pancreatic ductal adenocarcinoma (
  • Therapy target
    ANIMAL & CELL MODELS