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FLASH GENE
Symbol NCBP1 contributors: mct/ - updated : 29-01-2013
HGNC name nuclear cap binding protein subunit 1, 80kDa
HGNC id 7658
Location 9q22.33      Physical location : 100.395.704 - 100.436.027
Synonym name
  • NCBP 80 kDa subunit
  • cap-binding protein 80
  • Synonym symbol(s) CBP80, NCBP, RP11-546O6.1, MGC2087, Sto1
    DNA
    TYPE functioning gene
    SPECIAL FEATURE arranged in tandem
    STRUCTURE 40.33 kb     23 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Map cen - D9S287 - D9S1786 - NCBP1 - D9S272 - D9S176 - qter
    Physical map
    LOC158435 9q22.33 hypothetical protein BC008050 LOC286000 9q22.33 similar to hypothetical protein BC007171 HSD17B3 9q22.3 hydroxysteroid (17-beta) dehydrogenase 3 SLC35D2 9q22.33 solute carrier family 35, member D2 ZNF367 9q22 zinc finger protein 367 HABP4 9q22.3-q31 hyaluronan binding protein 4 CDC14B 9q22.32 CDC14 cell division cycle 14 homolog B (S. cerevisiae) C9orf21 9q22.32 chromosome 9 open reading frame 21 LOC286355 9q22.33 similar to hypothetical protein ZNF510 9q22.33 zinc finger protein 510 LOC158431 9q22.33 similar to zinc finger protein 11b (KOX 2) LOC347262 9q22.33 similar to hypothetical protein FLJ40432 LOC392369 9 similar to hypothetical protein HIATL2 9q22.33 hippocampus abundant gene transcript-like 2 CTSL2 9q22.2 cathepsin L2 TCEA1P 9q22.33 transcription elongation factor A (SII), 1 pseudogene LOC340508 9q22.33 hypothetical protein LOC340508 LOC389776 9 similar to RIKEN cDNA 2810453I06 LOC392370 9 similar to SNAG1 KIAA1529 9q22.33 KIAA1529 LOC389777 9 LOC389777 LOC286359 9q22.33 hypothetical protein LOC286359 PCTAIRE2BP 9q22.33 tudor repeat associator with PCTAIRE 2 TMOD1 9q22.32-q22.33 tropomodulin 1 LOC158427 9q22.33 PP4189 NCBP1 9q34.1 nuclear cap binding protein subunit 1, 80kDa XPA 9q22.32 xeroderma pigmentosum, complementation group A LOC392371 9 similar to Keratin, type I cytoskeletal 18 (Cytokeratin 18) (K18) (CK 18) FOXE1 9q22.3 forkhead box E1 (thyroid transcription factor 2) NAP1 19q13.33 pronapsin A HEMGN 9q22.33 hemogen ANP32B 9q22.32 acidic (leucine-rich) nuclear phosphoprotein 32 family, member B NANS 9p24.1-p23 N-acetylneuraminic acid synthase (sialic acid synthase) TRIM14 9q22.32 tripartite motif-containing 14 CORO2A 9q22.3 coronin, actin binding protein, 2A TBC1D2 9q22.33 TBC1 domain family, member 2 GPR51 9q22.1 G protein-coupled receptor 51 SAMD6 9q31.1 sterile alpha motif domain containing 6 GALNT12 9q22.33 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 12 (GalNAc-T12) LOC392372 9 similar to Nucleoside diphosphate kinase B (NDK B) (NDP kinase B) (P18) COL15A1 9q22.32-q22.33 collagen, type XV, alpha 1 TGFBR1 9q22 transforming growth factor, beta receptor I (activin A receptor type II-like kinase, 53kDa)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    23 - 5381 91.8 790 - 2007 17499042
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticspleen    
    Digestivemouth   highly
    Lymphoid/Immunethymus   highly
    Nervousbrain     Homo sapiens
    Visualeyeretina   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelial    
    Lymphoid    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    mono polymer heteromer , dimer
    HOMOLOGY
    interspecies homolog to murine Ncbp1
    Homologene
    FAMILY
  • NCBP1 family
  • CATEGORY DNA associated , transcription factor , transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm
    text present in the dendrites
    basic FUNCTION
  • maybe playing a role in pre-mRNA recognition and in the enhancement of pre-mRNA splicing
  • with LSM1, are translationally activated and contribute to the regulated local protein synthesis
  • CELLULAR PROCESS nucleotide, transcription, maturation
    PHYSIOLOGICAL PROCESS
    text premRNA
    PATHWAY
    metabolism
    signaling
    a component
  • component of the cap-binding protein complex in association with NCBP2 and other proteins, mediating premRNA splicing and export of U small nuclear RNAs to the cytoplasm
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with UPF1 and promotes the interaction of UPF1 with UPF2 but not with STAU1
  • NCBP1, NCBP2 independently interact with EIF4GI (EIF4G1 potentially serves to connect NCBP1/NCBP2 with other initiation factors during the pioneer round of translation)
  • LSM1-mRNPs contain the cap-binding protein NCBP1 that associates with (pre)mRNAs in the nucleus
  • UPF1 association with the cap-binding protein, NCBP1, promotes nonsense-mediated mRNA decay at two distinct steps
  • NCBP1/NCBP2 initially undergo a pioneer round of translation
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS