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FLASH GENE

Symbol

NCBP1

contributors: mct/ - updated : 29-01-2013

HGNC name	nuclear cap binding protein subunit 1, 80kDa
HGNC id	7658

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	9q22.33      Physical location : 100.395.704 - 100.436.027
Synonym name	NCBP 80 kDa subunit
	cap-binding protein 80
Synonym symbol(s)	CBP80, NCBP, RP11-546O6.1, MGC2087, Sto1

DNA

TYPE	functioning gene
SPECIAL FEATURE	arranged in tandem
STRUCTURE	40.33 kb     23 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

Map	cen - D9S287 - D9S1786 - NCBP1 - D9S272 - D9S176 - qter

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_002486 23 - 5381 NP_002477 91.8 790 - 2007 17499042

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol blood / hematopoietic spleen         Digestive mouth       highly Lymphoid/Immune thymus       highly Nervous brain         Homo sapiens Visual eye retina

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial         Lymphoid

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

mono polymer

heteromer , dimer

HOMOLOGY

interspecies

homolog to murine Ncbp1

Homologene

FAMILY

NCBP1 family

CATEGORY

DNA associated , transcription factor , transport

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytosolic
	intracellular,nucleus,nucleoplasm
text	present in the dendrites

basic FUNCTION	maybe playing a role in pre-mRNA recognition and in the enhancement of pre-mRNA splicing
	with LSM1, are translationally activated and contribute to the regulated local protein synthesis

CELLULAR PROCESS

nucleotide, transcription, maturation

PHYSIOLOGICAL PROCESS

text

premRNA

PATHWAY

metabolism

signaling

a component

component of the cap-binding protein complex in association with NCBP2 and other proteins, mediating premRNA splicing and export of U small nuclear RNAs to the cytoplasm

INTERACTION

DNA

RNA

small molecule

protein	interacts with UPF1 and promotes the interaction of UPF1 with UPF2 but not with STAU1
	NCBP1, NCBP2 independently interact with EIF4GI (EIF4G1 potentially serves to connect NCBP1/NCBP2 with other initiation factors during the pioneer round of translation)
	LSM1-mRNPs contain the cap-binding protein NCBP1 that associates with (pre)mRNAs in the nucleus
	UPF1 association with the cap-binding protein, NCBP1, promotes nonsense-mediated mRNA decay at two distinct steps
	NCBP1/NCBP2 initially undergo a pioneer round of translation

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS