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FLASH GENE
Symbol NCBP1 contributors: mct/ - updated : 29-01-2013
HGNC name nuclear cap binding protein subunit 1, 80kDa
HGNC id 7658
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
blood / hematopoieticspleen    
Digestivemouth   highly
Lymphoid/Immunethymus   highly
Nervousbrain     Homo sapiens
Visualeyeretina   
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelial    
Lymphoid    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer heteromer , dimer
HOMOLOGY
interspecies homolog to murine Ncbp1
Homologene
FAMILY
  • NCBP1 family
  • CATEGORY DNA associated , transcription factor , transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm
    text present in the dendrites
    basic FUNCTION
  • maybe playing a role in pre-mRNA recognition and in the enhancement of pre-mRNA splicing
  • with LSM1, are translationally activated and contribute to the regulated local protein synthesis
  • CELLULAR PROCESS nucleotide, transcription, maturation
    PHYSIOLOGICAL PROCESS
    text premRNA
    PATHWAY
    metabolism
    signaling
    a component
  • component of the cap-binding protein complex in association with NCBP2 and other proteins, mediating premRNA splicing and export of U small nuclear RNAs to the cytoplasm
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with UPF1 and promotes the interaction of UPF1 with UPF2 but not with STAU1
  • NCBP1, NCBP2 independently interact with EIF4GI (EIF4G1 potentially serves to connect NCBP1/NCBP2 with other initiation factors during the pioneer round of translation)
  • LSM1-mRNPs contain the cap-binding protein NCBP1 that associates with (pre)mRNAs in the nucleus
  • UPF1 association with the cap-binding protein, NCBP1, promotes nonsense-mediated mRNA decay at two distinct steps
  • NCBP1/NCBP2 initially undergo a pioneer round of translation
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS