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FLASH GENE
Symbol NCBP1 contributors: mct/ - updated : 29-01-2013
HGNC name nuclear cap binding protein subunit 1, 80kDa
HGNC id 7658
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer heteromer , dimer
HOMOLOGY
interspecies homolog to murine Ncbp1
Homologene
FAMILY
  • NCBP1 family
  • CATEGORY DNA associated , transcription factor , transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm
    text present in the dendrites
    basic FUNCTION
  • maybe playing a role in pre-mRNA recognition and in the enhancement of pre-mRNA splicing
  • with LSM1, are translationally activated and contribute to the regulated local protein synthesis
  • CELLULAR PROCESS nucleotide, transcription, maturation
    PHYSIOLOGICAL PROCESS
    text premRNA
    PATHWAY
    metabolism
    signaling
    a component
  • component of the cap-binding protein complex in association with NCBP2 and other proteins, mediating premRNA splicing and export of U small nuclear RNAs to the cytoplasm
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with UPF1 and promotes the interaction of UPF1 with UPF2 but not with STAU1
  • NCBP1, NCBP2 independently interact with EIF4GI (EIF4G1 potentially serves to connect NCBP1/NCBP2 with other initiation factors during the pioneer round of translation)
  • LSM1-mRNPs contain the cap-binding protein NCBP1 that associates with (pre)mRNAs in the nucleus
  • UPF1 association with the cap-binding protein, NCBP1, promotes nonsense-mediated mRNA decay at two distinct steps
  • NCBP1/NCBP2 initially undergo a pioneer round of translation
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS