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FLASH GENE

Symbol

NCAPG2

contributors: mct - updated : 29-01-2019

HGNC name	non-SMC condensin II complex, subunit G2
HGNC id	21904

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Corresponding disease	MRSRBD mental retardation syndromic with renal, brain and digit anomalies
Location	7q36.3      Physical location : 158.424.002 - 158.497.520
Synonym name	chromosome condensation protein G2
	leucine zipper protein 5
	chromosome-associated protein G2
	more than blood homolog
Synonym symbol(s)	FLJ20311, HCAPG2, LUZP5, MTB, CAP-G2, CAPG2, hCAP-G2

DNA

TYPE	functioning gene
STRUCTURE	73.66 kb     28 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_017760 28 - 4076 NP_060230 131 1143 - 2003 14532007 NM_001281932 29 - 4129 NP_001268861 - 1143 - 2003 14532007 NM_001281933 28 - 5337 NP_001268862 - 1156 - 2003 14532007

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive mouth         Lymphoid/Immune lymph node         Nervous brain         Skeleton axial skull face mandible

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / Hematopoietic bone marrow       Epithelial barrier/lining retinal pigment epithelium (RPE)     Lymphoid

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	three transmembrane domains
	five HEAT repeats

HOMOLOGY

Homologene

FAMILY

CATEGORY

DNA associated , transport

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles

basic FUNCTION	playing an essential role in mitotic chromosome assembly and segregation
	plays a novel function during erythropoiesis
	mediates chromosome segregation through microtubule-kinetochore attachment by recruiting PLK1 to prometaphase kinetochores
	contributes to chromosome segregation via microtubule-kinetochore attachment during mitosis

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

component of the condensin II complex

INTERACTION

DNA

RNA

small molecule

protein	MCPH1 and Condensin II interact, mediated by the CAPG2 subunit of Condensin II binding to a middle domain (residues 376-485) of MCPH1
	MCPH1 and NCAPG2 proteins interaction control chromosome structure, suggesting that double heterozygosity for null mutations of those two genes of the Condensin II system contribute to mental deficiency with severe microcephaly phenotype
	NCAPG2 colocalizes with PLK1 at prometaphase kinetochores and directly interacts with the polo-box domain (PBD) of PLK1 via its highly conserved C-terminal region
	mediates chromosome segregation through microtubule-kinetochore attachment by recruiting PLK1 to prometaphase kinetochores

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

MRSRBD

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in non-small cell lung cancer tissues compared to adjacent normal lung tissues, and significantly correlated with lymph node metastasis and pathologic-Tumour Nodes Metastasen stages

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	poor prognostic biomarker in lung adenocarcinoma
Therapy target
	System Type Disorder Pubmed cancer     simultaneous targeting of NCAPG2 and TRAPPC2 is a promising strategy for the development of antitumor drugs as a treatment for intractable tumours

ANIMAL & CELL MODELS

suppression and mutation of Ncapg2 results in apoptosis and altered mitotic progression in Zebrafish Larvae