protein
| MCPH1 and Condensin II interact, mediated by the CAPG2 subunit of Condensin II binding to a middle domain (residues 376-485) of MCPH1 |
|
MCPH1 and NCAPG2 proteins interaction control chromosome structure, suggesting that double heterozygosity for null mutations of those two genes of the Condensin II system contribute to mental deficiency with severe microcephaly phenotype |
|
NCAPG2 colocalizes with PLK1 at prometaphase kinetochores and directly interacts with the polo-box domain (PBD) of PLK1 via its highly conserved C-terminal region |
|
mediates chromosome segregation through microtubule-kinetochore attachment by recruiting PLK1 to prometaphase kinetochores |