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FLASH GENE
Symbol NARFL contributors: mct/npt - updated : 02/12/2008
HGNC name nuclear prelamin A recognition factor-like
HGNC id 14179
Location 16p13.3      Physical location : 779.770 - 790.997
Synonym name
  • LET1 like/JFP15
  • protein related to Narf
  • iron-only hydrogenase-like protein 1
  • Synonym symbol(s) LA16c-444G9.3, FLJ21988, HPRN, IOP1, LET1L, PRN
    DNA
    TYPE functioning gene
    SPECIAL FEATURE arranged in tandem
    STRUCTURE 11.23 kb     11 Exon(s)
    MAPPING cloned   linked N status provisional
    Physical map
    SOLH 16p13.3 small optic lobes homolog (Drosophila) LOC146325 16p13.3 similar to hypothetical protein FLJ13841 FLJ36208 16p13.3 hypothetical protein FLJ36208 PIGQ 16p13.3 phosphatidylinositol glycan, class Q RAB40C 16p13.3 RAB40C, member RAS oncogene family WFIKKN 16p13.3 RAB40C, member RAS oncogene family MGC13114 16p13.3 hypothetical protein MGC13114 LOC388198 16 LOC388198 MGC15416 16p13.3 hypothetical protein MGC15416 KIAA1924 16p13.3 hypothetical protein KIAA1924 LOC197336 16p13.3 similar to RIKEN cDNA 3230401M21 [Mus musculus] ARHT2 16p13.3 ras homolog gene family, member T2 RHBDL1 16p13.3 rhomboid, veinlet-like 1 (Drosophila) STUB1 16p13.3 STIP1 homology and U-Box containing protein 1 LOC339123 16p13.3 similar to RIKEN cDNA 2610003J06 DKFZp434F054 16p13.3 hypothetical protein DKFZp434F054 MGC33974 16p13.3 hypothetical protein MGC33974 MGC2601 16p13.3 hypothetical protein MGC2601 MGC2494 16p13.3 hypothetical protein MGC2494 FLJ34512 16p13.3 hypothetical protein FLJ34512 HAGHL 16p13.3 hydroxyacyl glutathione hydrolase-like NARFL 16p13.3 nuclear prelamin A recognition factor-like MSLN 16p13.3 mesothelin RLUCL CHTF18 16p13.3 CTF18, chromosome transmission fidelity factor 18 homolog (S. cerevisiae) GNG13 16p13.3 guanine nucleotide binding protein (G protein), gamma 13 LOC388199 16 LOC388199 FLJ12681 16p13.3 hypothetical protein FLJ12681
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    11 - 2109 53 476 - Huang (2007)
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunespleen   highly
     thymus   highly
    Reproductivefemale systemuteruscervix highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a small N-terminal region with a potential ferredoxin-like domain
  • a larger C-terminal domain that is homologous to the domain that contains the catalytic H-cluster of bacterial iron-only hydrogenases (Song 2009)
  • HOMOLOGY
    interspecies ortholog to S. Cerevisiae Nar1
    intraspecies homolog to IOP2
    Homologene
    FAMILY
  • NARF family
  • CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • playing a role in cytoplasmic Fe-S protein biogenesis in mammalian cells
  • modulator of HIF1A activity
  • involved in mammalian cytosolic Fe-S protein maturation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of the protein network that regulates HIF-1alpha in cells
  • INTERACTION
    DNA
    RNA
    small molecule
    protein interacting with ISCA1 (ISCA1 plays a role not only in the mitochondria but also directly in the cytosol through its interaction with NARFL) (Song 2009)
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS