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FLASH GENE
Symbol NARFL contributors: mct/npt - updated : 02/12/2008
HGNC name nuclear prelamin A recognition factor-like
HGNC id 14179
Location 16p13.3      Physical location : 779.770 - 790.997
Synonym name
  • LET1 like/JFP15
  • protein related to Narf
  • iron-only hydrogenase-like protein 1
  • Synonym symbol(s) LA16c-444G9.3, FLJ21988, HPRN, IOP1, LET1L, PRN
    DNA
    TYPE functioning gene
    SPECIAL FEATURE arranged in tandem
    STRUCTURE 11.23 kb     11 Exon(s)
    MAPPING cloned   linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    11 - 2109 53 476 - Huang (2007)
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunespleen   highly
     thymus   highly
    Reproductivefemale systemuteruscervix highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a small N-terminal region with a potential ferredoxin-like domain
  • a larger C-terminal domain that is homologous to the domain that contains the catalytic H-cluster of bacterial iron-only hydrogenases (Song 2009)
  • HOMOLOGY
    interspecies ortholog to S. Cerevisiae Nar1
    intraspecies homolog to IOP2
    Homologene
    FAMILY
  • NARF family
  • CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • playing a role in cytoplasmic Fe-S protein biogenesis in mammalian cells
  • modulator of HIF1A activity
  • involved in mammalian cytosolic Fe-S protein maturation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of the protein network that regulates HIF-1alpha in cells
  • INTERACTION
    DNA
    RNA
    small molecule
    protein interacting with ISCA1 (ISCA1 plays a role not only in the mitochondria but also directly in the cytosol through its interaction with NARFL) (Song 2009)
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS