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FLASH GENE
Symbol NARFL contributors: mct/npt - updated : 02/12/2008
HGNC name nuclear prelamin A recognition factor-like
HGNC id 14179
DNA
TYPE functioning gene
SPECIAL FEATURE arranged in tandem
STRUCTURE 11.23 kb     11 Exon(s)
MAPPING cloned   linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
11 - 2109 53 476 - Huang (2007)
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunespleen   highly
 thymus   highly
Reproductivefemale systemuteruscervix highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a small N-terminal region with a potential ferredoxin-like domain
  • a larger C-terminal domain that is homologous to the domain that contains the catalytic H-cluster of bacterial iron-only hydrogenases (Song 2009)
  • HOMOLOGY
    interspecies ortholog to S. Cerevisiae Nar1
    intraspecies homolog to IOP2
    Homologene
    FAMILY
  • NARF family
  • CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • playing a role in cytoplasmic Fe-S protein biogenesis in mammalian cells
  • modulator of HIF1A activity
  • involved in mammalian cytosolic Fe-S protein maturation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of the protein network that regulates HIF-1alpha in cells
  • INTERACTION
    DNA
    RNA
    small molecule
    protein interacting with ISCA1 (ISCA1 plays a role not only in the mitochondria but also directly in the cytosol through its interaction with NARFL) (Song 2009)
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS