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FLASH GENE
Symbol MYOM2 contributors: mct - updated : 10-06-2016
HGNC name myomesin (M-protein) 2, 165kDa
HGNC id 7614
Location 8p23.3      Physical location : 1.993.157 - 2.093.379
Synonym name
  • titin associated protein
  • M-band protein
  • 165 kDa connectin-associated protein
  • Synonym symbol(s) TTNAP, MYM2
    DNA
    TYPE functioning gene
    STRUCTURE 100.41 kb     37 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    37 - 5018 165 1465 - 2013 23792176
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousspinal cord   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumcardiac  
    Muscularstriatumskeletal  
    Nervouscentral   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text developing skeletal muscle fibers
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • unique terminal domain
  • 12 repeat domains
  • five fibronectin-like domains
  • three immunoglobulin-like C2 type domains
  • HOMOLOGY
    interspecies homolog to bovine M protein
    Homologene
    FAMILY
  • immunoglobulin superfamily
  • CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    basic FUNCTION
  • major component of myofibrillar band
  • expression is strongly and rapidly repressed by thyroid hormone (T3) in cardiomyocytes, which represents an important aspect for the basis of T3-dependent sarcomeric deleterious effects in the heart
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding myosin, titin, light meromyosin
  • DYSF interacts with CASQ1, MYOM2 and dynein in human skeletal muscle
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS