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FLASH GENE
Symbol MYOM2 contributors: mct - updated : 10-06-2016
HGNC name myomesin (M-protein) 2, 165kDa
HGNC id 7614
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • unique terminal domain
  • 12 repeat domains
  • five fibronectin-like domains
  • three immunoglobulin-like C2 type domains
  • HOMOLOGY
    interspecies homolog to bovine M protein
    Homologene
    FAMILY
  • immunoglobulin superfamily
  • CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    basic FUNCTION
  • major component of myofibrillar band
  • expression is strongly and rapidly repressed by thyroid hormone (T3) in cardiomyocytes, which represents an important aspect for the basis of T3-dependent sarcomeric deleterious effects in the heart
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding myosin, titin, light meromyosin
  • DYSF interacts with CASQ1, MYOM2 and dynein in human skeletal muscle
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS