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FLASH GENE
Symbol MYOM2 contributors: mct - updated : 10-06-2016
HGNC name myomesin (M-protein) 2, 165kDa
HGNC id 7614
DNA
TYPE functioning gene
STRUCTURE 100.41 kb     37 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
37 - 5018 165 1465 - 2013 23792176
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousspinal cord   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumcardiac  
Muscularstriatumskeletal  
Nervouscentral   
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text developing skeletal muscle fibers
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • unique terminal domain
  • 12 repeat domains
  • five fibronectin-like domains
  • three immunoglobulin-like C2 type domains
  • HOMOLOGY
    interspecies homolog to bovine M protein
    Homologene
    FAMILY
  • immunoglobulin superfamily
  • CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    basic FUNCTION
  • major component of myofibrillar band
  • expression is strongly and rapidly repressed by thyroid hormone (T3) in cardiomyocytes, which represents an important aspect for the basis of T3-dependent sarcomeric deleterious effects in the heart
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding myosin, titin, light meromyosin
  • DYSF interacts with CASQ1, MYOM2 and dynein in human skeletal muscle
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS