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FLASH GENE
Symbol MTMR12 contributors: - updated : 03-05-2006
HGNC name myotubularin related protein 12
HGNC id 18191
Location 5p15.33      Physical location : 32.227.111 - 32.313.114
Synonym name
  • phosphatidylinositol-3-phosphate associated protein
  • 3-phosphatase adapter subunit
  • phosphatidylinositol-3 phosphate 3-phosphatase adaptor subunit
    • Synonym symbol(s) 3-PAP, FLJ20476, KIAA1682, 3PAP, PIP3AP
    DNA
    TYPE functioning gene
    STRUCTURE 85.00 kb     17 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestivepharynx   highly
     salivary gland   highly
    Endocrinethyroid   highly
    Lymphoid/Immunelymph node   highly
    Nervousbrain    
    Urinarykidney    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a gram domain
  • a myotubularin-related domain
  • a tyrosine-protein phosphatase domain
    • HOMOLOGY
    interspecies homolog to murine Pip3ap
    Homologene
    FAMILY protein-tyrosine phosphatase family, non-receptor class myotubularin subfamily
    CATEGORY adaptor , receptor membrane tyrosine phosphatase
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    basic FUNCTION
  • lipid 3-phosphatase activity
  • function as an adaptator subunit in a complex with an active PtdIns(3)P 3-phosphatase
  • dual-specificity phosphatase acting on both phosphotyrosine and phosphoserine
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS