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FLASH GENE
Symbol MTMR12 contributors: - updated : 03-05-2006
HGNC name myotubularin related protein 12
HGNC id 18191
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Digestivepharynx   highly
 salivary gland   highly
Endocrinethyroid   highly
Lymphoid/Immunelymph node   highly
Nervousbrain    
Urinarykidney    
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a gram domain
  • a myotubularin-related domain
  • a tyrosine-protein phosphatase domain
    • HOMOLOGY
    interspecies homolog to murine Pip3ap
    Homologene
    FAMILY protein-tyrosine phosphatase family, non-receptor class myotubularin subfamily
    CATEGORY adaptor , receptor membrane tyrosine phosphatase
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    basic FUNCTION
  • lipid 3-phosphatase activity
  • function as an adaptator subunit in a complex with an active PtdIns(3)P 3-phosphatase
  • dual-specificity phosphatase acting on both phosphotyrosine and phosphoserine
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS