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FLASH GENE
Symbol MS4A1 contributors: - updated : 05-09-2007
HGNC name membrane-spanning 4-domains, subfamily A, member 1
HGNC id 7315
DNA
TYPE functioning gene
SPECIAL FEATURE component of a cluster
STRUCTURE 14.94 kb     8 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Promoter (TATA box)
MAPPING cloned Y linked Y status confirmed
Map see SEA
RNA
TRANSCRIPTS type messenger
text two transcripts encode the same protein
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
7 - 3331 - 297 - -
8 - 3594 - 297 - -
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   lowly
Digestivepharynx   highly
Lymphoid/Immunelymph node   highly
 spleen   highly
 thymus   highly
Nervousbrain   lowly
Reproductivemale systemtestis  lowly
Urinarykidney   lowly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoietic    
Connective    
Epithelialsecretoryglandularendocrine 
Epithelialsecretoryglandularexocrine 
Lymphoid    
cells
SystemCellPubmedSpeciesStageRna symbol
 mast cell
Lymphoid/ImmuneB cell
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a short intracellular domain
  • four transmembrane segments (4TM)
  • a long cytoplasmic tail, involved in intracellular signaling
  • mono polymer homomer , dimer
    HOMOLOGY
    interspecies homolog to murine Ms4a2 (83 pc)
    Homologene
    FAMILY
  • MS4A family
  • CATEGORY signaling , receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • involved in the regulation of B cell activation and proliferation
  • B cell-specific membrane protein that functions in store-operated calcium entry and serves as a useful target for antibody-mediated therapeutic depletion of B cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    PATHWAY
    metabolism
    signaling signal transduction
    a component
  • component of oligomeric cell surface complex involved in signal transduction
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
  • constitutively raft-associated
  • REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) CVID5
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS