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FLASH GENE
Symbol MS4A1 contributors: - updated : 05-09-2007
HGNC name membrane-spanning 4-domains, subfamily A, member 1
HGNC id 7315
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a short intracellular domain
  • four transmembrane segments (4TM)
  • a long cytoplasmic tail, involved in intracellular signaling
    • mono polymer homomer , dimer
    HOMOLOGY
    interspecies homolog to murine Ms4a2 (83 pc)
    Homologene
    FAMILY
  • MS4A family
    • CATEGORY signaling , receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • involved in the regulation of B cell activation and proliferation
  • B cell-specific membrane protein that functions in store-operated calcium entry and serves as a useful target for antibody-mediated therapeutic depletion of B cells
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    PATHWAY
    metabolism
    signaling signal transduction
    a component
  • component of oligomeric cell surface complex involved in signal transduction
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
  • constitutively raft-associated
    • REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) CVID5
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS