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FLASH GENE
Symbol MON1B contributors: mct - updated : 21-10-2011
HGNC name MON1 homolog B (yeast)
HGNC id 25020
Location 16q23.1      Physical location : 77.224.835 - 77.233.541
Synonym name
  • HSV-1 stimulation-related gene 1
  • protein MON1 homolog B
  • vacuolar fusion protein MON1 homolog B
    • Synonym symbol(s) SAND2, HSRG1, KIAA0872, SRG1
    DNA
    TYPE functioning gene
    STRUCTURE 8.71 kb     6 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 3328 - 547 - 2006 17109635
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Digestiveliver   lowly
    Nervousbrain   highly
    Respiratorylung   lowly
    Skin/Tegumentskin   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • five PKC phosphorylation sites
  • six myristoylation sites
  • a CAMP phosphorylation site
  • fiveCK2 phosphorylation sites
  • a tyr phosphorylation site
    • HOMOLOGY
    interspecies ortholog to murine Mon1b (85 pc)
    intraspecies homolog to MON1A
    Homologene
    FAMILY SAND protein family
    CATEGORY
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • required for phagosome maturation
  • virally induced protein expressed in HSV-1-infected cells, that is capable of interacting with transcriptional regulator proteins
  • likely inhibits viral gene transcriptional elongation by interacting with Cyclin T2
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    induced by in human fibroblasts induced by herpes simplex virus 1 binding
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS