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FLASH GENE
Symbol MON1B contributors: mct - updated : 21-10-2011
HGNC name MON1 homolog B (yeast)
HGNC id 25020
DNA
TYPE functioning gene
STRUCTURE 8.71 kb     6 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
6 - 3328 - 547 - 2006 17109635
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Digestiveliver   lowly
Nervousbrain   highly
Respiratorylung   lowly
Skin/Tegumentskin   highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • five PKC phosphorylation sites
  • six myristoylation sites
  • a CAMP phosphorylation site
  • fiveCK2 phosphorylation sites
  • a tyr phosphorylation site
  • HOMOLOGY
    interspecies ortholog to murine Mon1b (85 pc)
    intraspecies homolog to MON1A
    Homologene
    FAMILY SAND protein family
    CATEGORY
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • required for phagosome maturation
  • virally induced protein expressed in HSV-1-infected cells, that is capable of interacting with transcriptional regulator proteins
  • likely inhibits viral gene transcriptional elongation by interacting with Cyclin T2
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    induced by in human fibroblasts induced by herpes simplex virus 1 binding
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS