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FLASH GENE

Symbol

MMP21

contributors: mct - updated : 14-01-2015

HGNC name	matrix metalloproteinase 21
HGNC id	14357

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Corresponding disease	HTX7 heterotaxy, visceral, 7
Location	10q26.2      Physical location : 127.455.027 - 127.464.390
EC.number	3.4.24.-

DNA

TYPE	functioning gene
STRUCTURE	9.37 kb     7 Exon(s)

10 Kb 5' upstream gene genomic sequence study

regulatory sequence

Promoter (TATA box)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_147191 7 - 1919 NP_671724 - 569 - 2006 16984259

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine large intestine colon   lowly Nervous brain       lowly Reproductive female system ovary     lowly   male system testis     lowly Respiratory lung       lowly Urinary kidney       lowly

cells

System Cell Pubmed Species Stage Rna symbol Blood/Hematopoietic leukocyte Lymphoid/Immune macrophage Homo sapiens not specific fibroblast Homo sapiens

cell lineage
cell lines	ovarian and colon carcinomas, prostate cancer, breast cancer
fluid/secretion

at STAGE

physiological period

fetal, pregnancy

Text	placenta, fetal liver and brain

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

a N-terminal signal sequence, a prodomain, a vitronectin insert domain, a catalytic domain, a furin recognition sequence and a hemopexin-like domain

conjugated

HemoP , MetalloP

isoforms

Precursor

active form is 49kDa

HOMOLOGY

interspecies	homolog to murine Mmp21
	ortholog to xenopus XMMP

Homologene

FAMILY

matrix metalloproteinase (MMP) family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	extracellular
text	type I membrane protein

basic FUNCTION	involved in the breakdown of the extracellular matrix
	MMP21, MMP26 are not only associated with cancer but may be important in connective tissue remodelling and pathobiology of various benign skin disorders
	functions in embryogenesis and tumor progression
	may be an important protease in the terminal differentiation of keratinocytes
	potential role of MMP21 in the invasion and metastasis process of human colorectal cancer
	potential role of MMP21 in progression of gastric cancer

CELLULAR PROCESS

protein, degradation

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule	metal binding,
	Zn2+ binding

protein

binding TIMPs in a 1:1 stoechiometry

cell & other

REGULATION

activated by	cleavage of the prodomain by furin
	proteinases

inhibited by

TIMPs and TFPI2

ASSOCIATED DISORDERS

corresponding disease(s)

HTX7

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in colorectal cancer

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	might also be a novel molecular marker to predict overall survival of patients with gastric cancer
	independent prognostic factor in patients with stage II as well as stage III colorectal cancer
Therapy target

ANIMAL & CELL MODELS