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FLASH GENE
Symbol MMP21 contributors: mct - updated : 14-01-2015
HGNC name matrix metalloproteinase 21
HGNC id 14357
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
a N-terminal signal sequence, a prodomain, a vitronectin insert domain, a catalytic domain, a furin recognition sequence and a hemopexin-like domain
conjugated HemoP , MetalloP
isoforms Precursor active form is 49kDa
HOMOLOGY
interspecies homolog to murine Mmp21
ortholog to xenopus XMMP
Homologene
FAMILY matrix metalloproteinase (MMP) family
CATEGORY enzyme
SUBCELLULAR LOCALIZATION extracellular
text type I membrane protein
basic FUNCTION
  • involved in the breakdown of the extracellular matrix
  • MMP21, MMP26 are not only associated with cancer but may be important in connective tissue remodelling and pathobiology of various benign skin disorders
  • functions in embryogenesis and tumor progression
  • may be an important protease in the terminal differentiation of keratinocytes
  • potential role of MMP21 in the invasion and metastasis process of human colorectal cancer
  • potential role of MMP21 in progression of gastric cancer
  • CELLULAR PROCESS protein, degradation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    Zn2+ binding
    protein binding TIMPs in a 1:1 stoechiometry
    cell & other
    REGULATION
    activated by cleavage of the prodomain by furin
    proteinases
    inhibited by TIMPs and TFPI2
    ASSOCIATED DISORDERS
    corresponding disease(s) HTX7
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in colorectal cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • might also be a novel molecular marker to predict overall survival of patients with gastric cancer
  • independent prognostic factor in patients with stage II as well as stage III colorectal cancer
  • Therapy target
    ANIMAL & CELL MODELS