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FLASH GENE
Symbol MMP21 contributors: mct - updated : 14-01-2015
HGNC name matrix metalloproteinase 21
HGNC id 14357
DNA
TYPE functioning gene
STRUCTURE 9.37 kb     7 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Promoter (TATA box)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
7 - 1919 - 569 - 2006 16984259
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinelarge intestinecolon lowly
Nervousbrain   lowly
Reproductivefemale systemovary  lowly
 male systemtestis  lowly
Respiratorylung   lowly
Urinarykidney   lowly
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticleukocyte
Lymphoid/Immunemacrophage Homo sapiens
not specificfibroblast Homo sapiens
cell lineage
cell lines ovarian and colon carcinomas, prostate cancer, breast cancer
fluid/secretion
at STAGE
physiological period fetal, pregnancy
Text placenta, fetal liver and brain
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
a N-terminal signal sequence, a prodomain, a vitronectin insert domain, a catalytic domain, a furin recognition sequence and a hemopexin-like domain
conjugated HemoP , MetalloP
isoforms Precursor active form is 49kDa
HOMOLOGY
interspecies homolog to murine Mmp21
ortholog to xenopus XMMP
Homologene
FAMILY matrix metalloproteinase (MMP) family
CATEGORY enzyme
SUBCELLULAR LOCALIZATION extracellular
text type I membrane protein
basic FUNCTION
  • involved in the breakdown of the extracellular matrix
  • MMP21, MMP26 are not only associated with cancer but may be important in connective tissue remodelling and pathobiology of various benign skin disorders
  • functions in embryogenesis and tumor progression
  • may be an important protease in the terminal differentiation of keratinocytes
  • potential role of MMP21 in the invasion and metastasis process of human colorectal cancer
  • potential role of MMP21 in progression of gastric cancer
  • CELLULAR PROCESS protein, degradation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    Zn2+ binding
    protein binding TIMPs in a 1:1 stoechiometry
    cell & other
    REGULATION
    activated by cleavage of the prodomain by furin
    proteinases
    inhibited by TIMPs and TFPI2
    ASSOCIATED DISORDERS
    corresponding disease(s) HTX7
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in colorectal cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • might also be a novel molecular marker to predict overall survival of patients with gastric cancer
  • independent prognostic factor in patients with stage II as well as stage III colorectal cancer
  • Therapy target
    ANIMAL & CELL MODELS