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FLASH GENE

Symbol

MIB2

contributors: mct - updated : 17-01-2007

HGNC name	mindbomb homolog 2 (Drosophila)
HGNC id	30577

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	1p36.33      Physical location : 1.550.794 - 1.565.990
Synonym name	novelzin
	skeletrophin
	zinc finger, ZZ type with ankyrin repeat domain 1
Synonym symbol(s)	FLJ20648, FLJ39787, ZZANK1, ZZZ5
EC.number	6.3.2.-

DNA

TYPE	functioning gene
STRUCTURE	15.00 kb     20 Exon(s)

regulatory sequence	Promoter
	cytosine-phosphate-guanine/HTF
text structure	a promoter region of skeletrophin on a CpG island

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed skeletrophin alpha - splicing 3210 - 999 - Takeuchi, 2003 skeletrophin beta - splicing 3050 - 948 - Takeuchi, 2003 skeletrophin gamma - splicing 3240 - 1009 - Takeuchi, 2003

EXPRESSION

Type

widely

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive pancreas exocrine       predominantly Reproductive female system uterus cervix   moderately   male system prostate     lowly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	9 ANK repeats
	two MIB/HERC2 domains
	two RING-type zinc fingers
	a ZZ-type zinc finger

mono polymer

complex

HOMOLOGY

Homologene

FAMILY

CATEGORY

enzyme , signaling

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,endosome
text	colocalizes with endosomal compartments

basic FUNCTION	playing a role in the positive regulation of I-kappaB kinase/NF-kappaB cascade
	involved in protein ubiquitination
	E3 ubiquitin ligase protein that mediates ubiquitination of delta receptors, which act as
	ligands of Notch proteins
	RING (Really Interesting New Gene) finger-dependent ubiquitin ligase, which targets the intracellular region of Notch ligands
	might be a novel suppressor factor for melanoma invasion

CELLULAR PROCESS

protein, ubiquitin dependent proteolysis

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

signal transduction

I-kappaB kinase/NF-kappaB cascade

a component

ubiquitin ligase complex

INTERACTION

DNA

RNA

small molecule	metal binding,
	Zn2+

protein	interacts with actin monomer
	bound the intracellular regions of the Notch ligand Jagged-2, but not to those of Delta-1, -3, -4, or Jagged-1
	downregulates transcription of the Met oncogene, which encodes the hepatocyte growth factor receptor and plays a role in the determination of the invasive phenotype of many malignant tumors

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   aberrantly overexpressed in multiple myeloma cells, possibly activating HES1 on stromal cells through ligand-dependent Notch signaling tumoral     --low   in many melanomas

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS