Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol MIB2 contributors: mct - updated : 17-01-2007
HGNC name mindbomb homolog 2 (Drosophila)
HGNC id 30577
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • 9 ANK repeats
  • two MIB/HERC2 domains
  • two RING-type zinc fingers
  • a ZZ-type zinc finger
  • mono polymer complex
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY enzyme , signaling
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,endosome
    text colocalizes with endosomal compartments
    basic FUNCTION
  • playing a role in the positive regulation of I-kappaB kinase/NF-kappaB cascade
  • involved in protein ubiquitination
  • E3 ubiquitin ligase protein that mediates ubiquitination of delta receptors, which act as
  • ligands of Notch proteins
  • RING (Really Interesting New Gene) finger-dependent ubiquitin ligase, which targets the intracellular region of Notch ligands
  • might be a novel suppressor factor for melanoma invasion
  • CELLULAR PROCESS protein, ubiquitin dependent proteolysis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
  • I-kappaB kinase/NF-kappaB cascade
  • a component
  • ubiquitin ligase complex
  • INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
  • interacts with actin monomer
  • bound the intracellular regions of the Notch ligand Jagged-2, but not to those of Delta-1, -3, -4, or Jagged-1
  • downregulates transcription of the Met oncogene, which encodes the hepatocyte growth factor receptor and plays a role in the determination of the invasive phenotype of many malignant tumors
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    aberrantly overexpressed in multiple myeloma cells, possibly activating HES1 on stromal cells through ligand-dependent Notch signaling
    tumoral     --low  
    in many melanomas
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS