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FLASH GENE
Symbol MIB2 contributors: mct - updated : 17-01-2007
HGNC name mindbomb homolog 2 (Drosophila)
HGNC id 30577
DNA
TYPE functioning gene
STRUCTURE 15.00 kb     20 Exon(s)
regulatory sequence Promoter
cytosine-phosphate-guanine/HTF
text structure a promoter region of skeletrophin on a CpG island
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- splicing 3210 - 999 - Takeuchi, 2003
- splicing 3050 - 948 - Takeuchi, 2003
- splicing 3240 - 1009 - Takeuchi, 2003
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivepancreas exocrine   predominantly
Reproductivefemale systemuteruscervix moderately
 male systemprostate  lowly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • 9 ANK repeats
  • two MIB/HERC2 domains
  • two RING-type zinc fingers
  • a ZZ-type zinc finger
  • mono polymer complex
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY enzyme , signaling
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,endosome
    text colocalizes with endosomal compartments
    basic FUNCTION
  • playing a role in the positive regulation of I-kappaB kinase/NF-kappaB cascade
  • involved in protein ubiquitination
  • E3 ubiquitin ligase protein that mediates ubiquitination of delta receptors, which act as
  • ligands of Notch proteins
  • RING (Really Interesting New Gene) finger-dependent ubiquitin ligase, which targets the intracellular region of Notch ligands
  • might be a novel suppressor factor for melanoma invasion
  • CELLULAR PROCESS protein, ubiquitin dependent proteolysis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
  • I-kappaB kinase/NF-kappaB cascade
  • a component
  • ubiquitin ligase complex
  • INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
  • interacts with actin monomer
  • bound the intracellular regions of the Notch ligand Jagged-2, but not to those of Delta-1, -3, -4, or Jagged-1
  • downregulates transcription of the Met oncogene, which encodes the hepatocyte growth factor receptor and plays a role in the determination of the invasive phenotype of many malignant tumors
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    aberrantly overexpressed in multiple myeloma cells, possibly activating HES1 on stromal cells through ligand-dependent Notch signaling
    tumoral     --low  
    in many melanomas
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS