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FLASH GENE
Symbol MAX contributors: mct - updated : 04-05-2011
HGNC name MYC associated factor X
HGNC id 6913
Location 14q23.3      Physical location : 65.472.891 - 65.569.227
Synonym name
  • MAX protein
  • class D basic helix-loop-helix protein 4
    • Synonym symbol(s) orf1, MGC10775, MGC11225, MGC18164, MGC34679, MGC36767, bHLHd4, bHLHd5, bHLHd6, bHLHd7, bHLHd8
    DNA
    TYPE functioning gene
    STRUCTURE 96.34 kb     5 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Physical map
    LOC390485 14 similar to ribosomal protein L31 GCATP 14q23.2 glycine C-acetyltransferase pseudogene LOC112840 14q23.2 similar to RIKEN cDNA 2600001A11 gene HSPEP2 14 heat shock 10kDa protein 1 (chaperonin 10) pseudogene 2 SGPP1 14q23.1 sphingosine-1-phosphate phosphatase 1 EIF2S2P 14q23.2 eukaryotic translation initiation factor 2, subunit 2 beta, pseudogene SYNE2 14q23.1-q23.2 spectrin repeat containing, nuclear envelope 2 ESR2 14q24.1 estrogen receptor 2 (ER beta) MTHFD1 14q24 methylenetetrahydrofolate dehydrogenase (NADP+ dependent), methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase AKAP5 14q21-q24 a kinase (PRKA) anchor protein 5 ZNF46 14q22-q24 zinc finger protein 46 (KUP) ZBTB1 14q22.1-q22.3 zinc finger and BTB domain containing 1 HSPA2 14q22 heat shock 70kDa protein 2 C14orf50 14q23.2 chromosome 14 open reading frame 50 NUP50P 14 nucleoporin 50 pseudogene KIAA0599 14q23.3 KIAA0599 SPTB 14q22-q23.2 spectrin, beta, erythrocytic (includes spherocytosis, clinical type I) C14orf52 14q23.2 chromosome 14 open reading frame 52 GPX2 14q24.1 glutathione peroxidase 2 (gastrointestinal) LOC390487 14 similar to Ras-related protein Rab-15 FNTB 14q23.1 farnesyltransferase, CAAX box, beta MAX 14q23.1 MAX protein LOC390488 14 similar to 60S ribosomal protein L21 RPL36AP2 14 ribosomal protein L36a pseudogene 2 PTBP1P 14 polypyrimidine tract binding protein 1 pseudogene FUT8 14q24.3 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) RPL21P8 14 ribosomal protein L21 pseudogene 8 NCOA4P 14 nuclear receptor coactivator 4 pseudogene LOC390489 14 similar to Ferritin heavy chain (Ferritin H subunit) NSEP1P 14q23.2 nuclease sensitive element binding protein 1 pseudogene LOC122438 14q23.3 similar to RIKEN cDNA 1110013H04
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 2068 18.3 160 - 2011 21685915
  • including the bHLHZip domain (AAs 22 to 102) and the casein kinase II phosphorylation sites
    • - - 1900 - ? - -
  • truncated at the C terminus
  • lacking the NLS
    • 4 - 2041 - 151 - 2006 16475822
    6 - 2169 - 103 - 2006 16475822
    4 - 942 - 96 - 2006 16475822
    4 - 575 - 134 - 2006 16475822
    4 - 452 - 83 - 2006 16475822
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon highly
     mouth   highly
     pharynx   highly
    Nervousbrain   highly
    Respiratorylung   highly
    Urinarykidney   lowly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • basic helix-loop-helix (HLH)
  • leucine zipper domains
  • a nuclear localization signal (NLS)
    • mono polymer heteromer , dimer
    HOMOLOGY
    Homologene
    FAMILY
  • basic helix-loop-helix leucine zipper (bHLHZ) family of transcription factors
    • CATEGORY transcription factor , tumor suppressor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • MYC-MAX complex is a transcriptional activator, whereas the MAD-MAX complex is a repressor
  • is the obligatory DNA-binding and dimerization partner for all the bHLHZip regulators of the Myc/Max/Mad network, including the Myc family of oncoproteins and the Mad family of Myc antagonists, which recognize E-box DNA elements in the regulatory regions of target genes
  • is a constitutively expressed and phosphorylated protein
  • key role for the MYC-MAX-MXD1 network in the development and progression of neural crest tumors
    • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
  • heterodimerizing with MYC, with high affinity for the DNA-binding site of MYC (transcriptional activator)
  • heterodimerizing with MAD (transcriptional repressor)
  • forms a specific DNA-binding complex with MYC
  • part of the MYC-MAX-MXD1 network
    • INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • MAD and MNT binding
  • requires dimerization with another bHLH protein to efficient DNA binding
  • MYC and MNT use MAX as a cofactor for DNA binding
  • MYC, ZBTB17 and MAX are associated with the CEBPD promoter in proliferating cells, when CEBPD expression is repressed
  • deacetylation of MYC by SIRT1 promotes its association with MAX, a partner essential for its activation, thereby facilitating MYC transactivation activity on TERT promoter
    • cell & other
    REGULATION
    Other acetylated at the three MAX AA by EP300, which is important for MAX nuclear localization and MAX-mediated suppression of MYC transactivation
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral germinal mutation      
    in hereditary pheochromocytoma, with metastatic potential
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS