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FLASH GENE

Symbol

MAX

contributors: mct - updated : 04-05-2011

HGNC name	MYC associated factor X
HGNC id	6913

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	14q23.3      Physical location : 65.472.891 - 65.569.227
Synonym name	MAX protein
	class D basic helix-loop-helix protein 4
Synonym symbol(s)	orf1, MGC10775, MGC11225, MGC18164, MGC34679, MGC36767, bHLHd4, bHLHd5, bHLHd6, bHLHd7, bHLHd8

DNA

TYPE	functioning gene
STRUCTURE	96.34 kb     5 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_002382 5 - 2068 NP_002373 18.3 160 - 2011 21685915 including the bHLHZip domain (AAs 22 to 102) and the casein kinase II phosphorylation sites variant delta - - 1900 isoform delta - ? - - truncated at the C terminus lacking the NLS NM_145112 4 - 2041 NP_660087 - 151 - 2006 16475822 NM_145113 6 - 2169 NP_660088 - 103 - 2006 16475822 NM_145114 4 - 942 NP_660089 - 96 - 2006 16475822 NM_145116 4 - 575 NP_660092 - 134 - 2006 16475822 NM_197957 4 - 452 NP_932061 - 83 - 2006 16475822

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine large intestine colon   highly   mouth       highly   pharynx       highly Nervous brain       highly Respiratory lung       highly Urinary kidney       lowly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular striatum skeletal

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	basic helix-loop-helix (HLH)
	leucine zipper domains
	a nuclear localization signal (NLS)

mono polymer

heteromer , dimer

HOMOLOGY

Homologene

FAMILY

basic helix-loop-helix leucine zipper (bHLHZ) family of transcription factors

CATEGORY

transcription factor , tumor suppressor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm
	intracellular,nucleus

basic FUNCTION	MYC-MAX complex is a transcriptional activator, whereas the MAD-MAX complex is a repressor
	is the obligatory DNA-binding and dimerization partner for all the bHLHZip regulators of the Myc/Max/Mad network, including the Myc family of oncoproteins and the Mad family of Myc antagonists, which recognize E-box DNA elements in the regulatory regions of target genes
	is a constitutively expressed and phosphorylated protein
	key role for the MYC-MAX-MXD1 network in the development and progression of neural crest tumors

CELLULAR PROCESS

nucleotide, transcription, regulation

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

signal transduction

a component	heterodimerizing with MYC, with high affinity for the DNA-binding site of MYC (transcriptional activator)
	heterodimerizing with MAD (transcriptional repressor)
	forms a specific DNA-binding complex with MYC
	part of the MYC-MAX-MXD1 network

INTERACTION

DNA

binding

RNA

small molecule

protein	MAD and MNT binding
	requires dimerization with another bHLH protein to efficient DNA binding
	MYC and MNT use MAX as a cofactor for DNA binding
	MYC, ZBTB17 and MAX are associated with the CEBPD promoter in proliferating cells, when CEBPD expression is repressed
	deacetylation of MYC by SIRT1 promotes its association with MAX, a partner essential for its activation, thereby facilitating MYC transactivation activity on TERT promoter

cell & other

REGULATION

Other

acetylated at the three MAX AA by EP300, which is important for MAX nuclear localization and MAX-mediated suppression of MYC transactivation

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral germinal mutation       in hereditary pheochromocytoma, with metastatic potential

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS