Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol MAX contributors: mct - updated : 04-05-2011
HGNC name MYC associated factor X
HGNC id 6913
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • basic helix-loop-helix (HLH)
  • leucine zipper domains
  • a nuclear localization signal (NLS)
  • mono polymer heteromer , dimer
    HOMOLOGY
    Homologene
    FAMILY
  • basic helix-loop-helix leucine zipper (bHLHZ) family of transcription factors
  • CATEGORY transcription factor , tumor suppressor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • MYC-MAX complex is a transcriptional activator, whereas the MAD-MAX complex is a repressor
  • is the obligatory DNA-binding and dimerization partner for all the bHLHZip regulators of the Myc/Max/Mad network, including the Myc family of oncoproteins and the Mad family of Myc antagonists, which recognize E-box DNA elements in the regulatory regions of target genes
  • is a constitutively expressed and phosphorylated protein
  • key role for the MYC-MAX-MXD1 network in the development and progression of neural crest tumors
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
  • heterodimerizing with MYC, with high affinity for the DNA-binding site of MYC (transcriptional activator)
  • heterodimerizing with MAD (transcriptional repressor)
  • forms a specific DNA-binding complex with MYC
  • part of the MYC-MAX-MXD1 network
  • INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • MAD and MNT binding
  • requires dimerization with another bHLH protein to efficient DNA binding
  • MYC and MNT use MAX as a cofactor for DNA binding
  • MYC, ZBTB17 and MAX are associated with the CEBPD promoter in proliferating cells, when CEBPD expression is repressed
  • deacetylation of MYC by SIRT1 promotes its association with MAX, a partner essential for its activation, thereby facilitating MYC transactivation activity on TERT promoter
  • cell & other
    REGULATION
    Other acetylated at the three MAX AA by EP300, which is important for MAX nuclear localization and MAX-mediated suppression of MYC transactivation
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral germinal mutation      
    in hereditary pheochromocytoma, with metastatic potential
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS