basic FUNCTION
| MYC-MAX complex is a transcriptional activator, whereas the MAD-MAX complex is a repressor |
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is the obligatory DNA-binding and dimerization partner for all the bHLHZip regulators of the Myc/Max/Mad network, including the Myc family of oncoproteins and the Mad family of Myc antagonists, which recognize E-box DNA elements in the regulatory regions of target genes |
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is a constitutively expressed and phosphorylated protein |
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key role for the MYC-MAX-MXD1 network in the development and progression of neural crest tumors |
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MAX prevents ectopic and precocious meiosis in embryonic stem cells (ESCs) and germ cells, respectively |
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"clock" function of MAX is required for maintaining a proper circadian rhythm and MAX and ARNTL contribute to two temporally alternating transcriptional complexes on clock-regulated promoters |
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MAX regulates clock gene expression and contributes to keeping the balance between positive and negative elements of the molecular clock machinery |