Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol MARCH4 contributors: mct - updated : 31-10-2012
HGNC name membrane-associated ring finger (C3HC4) 4
HGNC id 29269
Location 2q35      Physical location : 217.122.585 - 217.236.750
Synonym name
  • RING finger protein 174
  • membrane-associated RING-CH protein IV
  • Synonym symbol(s) RNF174, MARCH-IV, KIAA1399, MGC104908
    EC.number 6.3.2.-
    DNA
    TYPE functioning gene
    STRUCTURE 114.16 kb     4 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 4466 - 410 - 2010 21151997
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver   lowly
     pancreas exocrine   lowly
    Nervousbrain   moderately
    Respiratorylung   highly
    Skin/Tegumentskin   predominantly
    cell lineage
    cell lines
    fluid/secretion blood
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a RING-type zinc finger
  • mono polymer complex
    HOMOLOGY
    Homologene
    FAMILY
  • MARCH family of membrane-bound E3 ubiquitin ligases
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    text integral to membrane
    basic FUNCTION
  • acting as a ubiquitin-protein ligase
  • role of MARCH8 and MARCH4 in the regulated turnover of CD81 and CD44, two ubiquitously expressed, multifunctional proteins
  • MARCH E3 ligases play a key role in controlling MHC class II surface expression by regulated ubiquitination of a lysine residue in the beta-chain
  • CELLULAR PROCESS protein, ubiquitin dependent proteolysis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • ubiquitin ligase complex
  • INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
  • ULBP1 is a target for the MARCH family of E3 ligases, MARCH4 and MARCH9, suggesting that induction of ULBP1 in response to heat shock is due to regulated association with its E3 ligases
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS