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FLASH GENE
Symbol MARCH4 contributors: mct - updated : 31-10-2012
HGNC name membrane-associated ring finger (C3HC4) 4
HGNC id 29269
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a RING-type zinc finger
    • mono polymer complex
    HOMOLOGY
    Homologene
    FAMILY
  • MARCH family of membrane-bound E3 ubiquitin ligases
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    text integral to membrane
    basic FUNCTION
  • acting as a ubiquitin-protein ligase
  • role of MARCH8 and MARCH4 in the regulated turnover of CD81 and CD44, two ubiquitously expressed, multifunctional proteins
  • MARCH E3 ligases play a key role in controlling MHC class II surface expression by regulated ubiquitination of a lysine residue in the beta-chain
    • CELLULAR PROCESS protein, ubiquitin dependent proteolysis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • ubiquitin ligase complex
    • INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+
    • protein
  • ULBP1 is a target for the MARCH family of E3 ligases, MARCH4 and MARCH9, suggesting that induction of ULBP1 in response to heat shock is due to regulated association with its E3 ligases
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS